GEESI, Mohammed; RIADI, Yassine; KAIBA, Abdellah; ANOUAR, El Hassane; OUERGHI, Oussama; IBNOUF, Elmutasim; GUIONNEAU, Philippe

doi:10.1016/j.molstruc.2020.128265

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GEESI, Mohammed
Department of Chemistry

RIADI, Yassine
Department of Pharmaceutical Chemistry

KAIBA, Abdellah
Department of Physic

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Journal of Molecular Structure. 2020-09, vol. 1215, p. 128265 (7 p.)

Elsevier

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An efficient route was reported for synthesis of a novel 3-(4-fluorophenyl)-6-methyl-2-(propylthio)quinazolin-4(3H)-one. The synthesized compound was prepared by a sulphur arylation reaction and was tested against some bacterial strains. Raman analysis was conducted on the synthesized derivative, which had the following properties: empirical formula (C18H17Cl N2 O), system (monoclinic), space group (P21/c), unit parameters cell (a = 12.7137(7) Å, b = 7.5018(4) Å, c = 17.1209(9) Å and β =11.0042(15)°), volume (V = 1524.42 Å3), Z = 4, temperature (150 (2) K). The single crystal structure was resolved and refined to (R = 0.0374, wR = 0.1040). The non-hydrogen atoms were refined anisotropically and the hydrogen atoms were placed theoretically. The Hirshfeld surface and fingerprint plots were obtained. The electrostatic potential surface (ESP) was also derived using the density functional theory method.< Leer menos

Palabras clave en inglés

3-(4-Fluorophenyl)-6-methyl-2-(propylthio)quinazolin-4(3H)-one

Antibacterial

Crystal structure

Hirshfeld surface analysis

Electrostatic potential surface

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Synthesis, antibacterial evaluation, Raman, crystal structure and Hirshfeld surface analysis of a new 3-(4-fluorophenyl)-6-methyl-2-(propylthio)quinazolin-4(3H)-one

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