Synthesis, antibacterial evaluation, Raman, crystal structure and Hirshfeld surface analysis of a new 3-(4-fluorophenyl)-6-methyl-2-(propylthio)quinazolin-4(3H)-one
Language
en
Article de revue
This item was published in
Journal of Molecular Structure. 2020-09, vol. 1215, p. 128265 (7 p.)
Elsevier
English Abstract
An efficient route was reported for synthesis of a novel 3-(4-fluorophenyl)-6-methyl-2-(propylthio)quinazolin-4(3H)-one. The synthesized compound was prepared by a sulphur arylation reaction and was tested against some ...Read more >
An efficient route was reported for synthesis of a novel 3-(4-fluorophenyl)-6-methyl-2-(propylthio)quinazolin-4(3H)-one. The synthesized compound was prepared by a sulphur arylation reaction and was tested against some bacterial strains. Raman analysis was conducted on the synthesized derivative, which had the following properties: empirical formula (C18H17Cl N2 O), system (monoclinic), space group (P21/c), unit parameters cell (a = 12.7137(7) Å, b = 7.5018(4) Å, c = 17.1209(9) Å and β =11.0042(15)°), volume (V = 1524.42 Å3), Z = 4, temperature (150 (2) K). The single crystal structure was resolved and refined to (R = 0.0374, wR = 0.1040). The non-hydrogen atoms were refined anisotropically and the hydrogen atoms were placed theoretically. The Hirshfeld surface and fingerprint plots were obtained. The electrostatic potential surface (ESP) was also derived using the density functional theory method.Read less <
English Keywords
3-(4-Fluorophenyl)-6-methyl-2-(propylthio)quinazolin-4(3H)-one
Antibacterial
Crystal structure
Hirshfeld surface analysis
Electrostatic potential surface
Origin
Hal imported