Synthesis, antibacterial evaluation, crystal structure, molecular interaction analysis and DFT calculations of novel N-hydroxy-2-(4-methylbenzamido)benzamide
AZZALLOU, Rachid
Laboratoire de biochimie, environnement et agroalimentaire, URAC 36, FSTM, Université Hassan II Casablanca
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Laboratoire de biochimie, environnement et agroalimentaire, URAC 36, FSTM, Université Hassan II Casablanca
Language
en
Article de revue
This item was published in
Journal of Molecular Structure. 2021, vol. 1246, p. 131214 (14)
Elsevier
English Abstract
In this study, an efficient strategy for the synthesis of a new benzamide derivative N-hydroxy-2-(4-methylbenzamido)benzamide was reported by using readily available reagents, and its antibacterial activity against bacterial ...Read more >
In this study, an efficient strategy for the synthesis of a new benzamide derivative N-hydroxy-2-(4-methylbenzamido)benzamide was reported by using readily available reagents, and its antibacterial activity against bacterial strains was investigated. This new compound crystallized in a monoclinic system with the P21/n space group. Its unit-cell parameters were a = 7.5103(2) Å, b = 11.7991(3) Å, c = 15.2645(4) Å, β = 91.907(2)° and Z = 4. Crystal packing was stabilized by hydrogen bonds and π-stacking interactions and van der Waals interactions. Hirshfeld surfaces and their associated two-dimensional fingerprint plots were utilized to analyze the intermolecular interactions in the crystal structure. In addition, electrostatic surface potential (ESP) was generated by the density functional theory.Read less <
English Keywords
Benzamide
Antibacterial activity
Crystal structure
Hirshfeld surface analysis
Origin
Hal imported