Synthesis, antibacterial evaluation, crystal structure, molecular interaction analysis and DFT calculations of novel N-hydroxy-2-(4-methylbenzamido)benzamide
AZZALLOU, Rachid
Laboratoire de biochimie, environnement et agroalimentaire, URAC 36, FSTM, Université Hassan II Casablanca
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Laboratoire de biochimie, environnement et agroalimentaire, URAC 36, FSTM, Université Hassan II Casablanca
Langue
en
Article de revue
Ce document a été publié dans
Journal of Molecular Structure. 2021, vol. 1246, p. 131214 (14)
Elsevier
Résumé en anglais
In this study, an efficient strategy for the synthesis of a new benzamide derivative N-hydroxy-2-(4-methylbenzamido)benzamide was reported by using readily available reagents, and its antibacterial activity against bacterial ...Lire la suite >
In this study, an efficient strategy for the synthesis of a new benzamide derivative N-hydroxy-2-(4-methylbenzamido)benzamide was reported by using readily available reagents, and its antibacterial activity against bacterial strains was investigated. This new compound crystallized in a monoclinic system with the P21/n space group. Its unit-cell parameters were a = 7.5103(2) Å, b = 11.7991(3) Å, c = 15.2645(4) Å, β = 91.907(2)° and Z = 4. Crystal packing was stabilized by hydrogen bonds and π-stacking interactions and van der Waals interactions. Hirshfeld surfaces and their associated two-dimensional fingerprint plots were utilized to analyze the intermolecular interactions in the crystal structure. In addition, electrostatic surface potential (ESP) was generated by the density functional theory.< Réduire
Mots clés en anglais
Benzamide
Antibacterial activity
Crystal structure
Hirshfeld surface analysis
Origine
Importé de halUnités de recherche