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Investigating nucleation and growth phenomena in microfluidic supercritical antisolvent process by coupling in situ fluorescence spectroscopy and direct numerical simulation

hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorJAOUHARI, Thomas
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARRE, Samuel
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorTASSAING, Thierry
hal.structure.identifierSynthèse et Physico-Chimie de Molécules d'Intérêt Biologique [SPCMIB]
dc.contributor.authorFERY-FORGUES, Suzanne
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorAYMONIER, Cyril
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorERRIGUIBLE, Arnaud
dc.date.issued2022-02
dc.identifier.issn0009-2509
dc.description.abstractEnHigh-pressure microfluidic systems exhibit favorable capacity to enhance mixing quality compared to conventional macroscale liquid systems. These mixing conditions are very interesting for the preparation of fluorescent organic nanoparticles by supercritical antisolvent process. In this work, fundamental mechanisms of microfluidic supercritical antisolvent process (µSAS) including thermodynamics, hydrodynamics, nucleation/growth phenomena, are investigated using a coupled experimental/simulation approach. Specifically, we determined experimentally the particle precipitation field in a CO2 / solvent medium using a fluorescent organic dye molecule which presents an enhancement of fluorescence intensity in its aggregated state (AIE effect). The results of the direct numerical simulation considering all the physical phenomena are compared with the experimental data for validation and deep understanding of the mechanisms. It is shown that despite ultra-short mixing time, the supersaturation field showed some fluctuation leading to variation of the nucleation times.
dc.description.sponsorshipSynthèse de nanocristaux organiques fluorescents en milieu fluide supercritique: une approche numérique et expérimentale complémentaire - ANR-17-CE07-0029
dc.language.isoen
dc.publisherElsevier
dc.subject.enSupercritical fluids
dc.subject.enPrecipitation
dc.subject.enMixing
dc.subject.enMicrofluidic
dc.subject.enCFD
dc.title.enInvestigating nucleation and growth phenomena in microfluidic supercritical antisolvent process by coupling in situ fluorescence spectroscopy and direct numerical simulation
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ces.2021.117240
dc.subject.halChimie/Matériaux
bordeaux.journalChemical Engineering Science
bordeaux.page117240 (11 p.)
bordeaux.volume248
bordeaux.issuePart B
bordeaux.peerReviewedoui
hal.identifierhal-03436269
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03436269v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Chemical%20Engineering%20Science&rft.date=2022-02&rft.volume=248&rft.issue=Part%20B&rft.spage=117240%20(11%20p.)&rft.epage=117240%20(11%20p.)&rft.eissn=0009-2509&rft.issn=0009-2509&rft.au=JAOUHARI,%20Thomas&MARRE,%20Samuel&TASSAING,%20Thierry&FERY-FORGUES,%20Suzanne&AYMONIER,%20Cyril&rft.genre=article


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