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Synthesis, crystal structure and anti-leukemic activity of 4-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-3-phenyl-3H-pyrrolo[2,3-c]quinoline

hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorGUILLON, Jean
hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorMOREAU, Stéphane
hal.structure.identifierCellules souches hématopoïétiques normales et leucémiques
dc.contributor.authorDESPLAT, Vanessa
hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorVINCENZI, Marian
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorPINAUD, Noël
hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorSAVRIMOUTOU, Solène
hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorRUBIO, Sandra
hal.structure.identifierAcides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
dc.contributor.authorRONGA, Luisa
hal.structure.identifierUniversity of Naples Federico II = Università degli studi di Napoli Federico II
dc.contributor.authorROSSI, Filomena
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARCHIVIE, Mathieu
dc.date.issued2019
dc.identifier.issn1074-1542
dc.description.abstractEnThe title compound 4-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-3-phenyl-3H-pyrrolo[2,3-c]quinoline 1, a compound that showed cytotoxic potential against two leukemia cell lines, has been synthesized via a multi-step pathway. This compound was characterized by single-crystal X-ray diffraction, IR, MS, elemental analysis, 1H and 13C NMR. The crystal (C37H33H5O, Mr = 563.68) belongs to orthorhombic, space group Pbcn with cell parameters a = 30.198(2) Å, b = 12.5097(11) Å, c = 15.6648(13) Å, V = 5917.7(8) Å3, Z = 8, Dc = 1.265 g/cm3, CuKα radiation, λ = 1.54180 Å, µ = 0.611 mm−1, F(000) = 2384, the final R = 0.0491 and wR = 0.1585 for 5698 observed reflections with I > 2σ(I).
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enAntileukemial
dc.subject.enPyrrolo[2
dc.subject.en3-c]quinoline
dc.subject.enHeterocycle
dc.title.enSynthesis, crystal structure and anti-leukemic activity of 4-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-3-phenyl-3H-pyrrolo[2,3-c]quinoline
dc.typeArticle de revue
dc.identifier.doi10.1007/s10870-018-0734-2
dc.subject.halChimie/Chimie thérapeutique
dc.subject.halChimie/Cristallographie
bordeaux.journalJournal of Chemical Crystallography
bordeaux.page106-112
bordeaux.volume49
bordeaux.issue2
bordeaux.peerReviewedoui
hal.identifierhal-02130098
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02130098v1
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