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Reactive precipitation of vaterite calcium carbonate microspheres in supercritical carbon dioxide-water dispersion by microfluidics

hal.structure.identifierMicro et Nanomédecines Translationnelles [MINT]
hal.structure.identifierInstitut des Molécules et Matériaux du Mans [IMMM]
dc.contributor.authorLEGOUT, Pierre
hal.structure.identifierMicro et Nanomédecines Translationnelles [MINT]
dc.contributor.authorLEFEBVRE, Guillaume
hal.structure.identifierMicro et Nanomédecines Translationnelles [MINT]
dc.contributor.authorBONNIN, Marie
hal.structure.identifierMicro et Nanomédecines Translationnelles [MINT]
dc.contributor.authorGIMEL, Jean Christophe
hal.structure.identifierInstitut des Molécules et Matériaux du Mans [IMMM]
dc.contributor.authorBENYAHIA, L.
hal.structure.identifierInstitut des Molécules et Matériaux du Mans [IMMM]
dc.contributor.authorGIBAUD, Alain
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARRE, Samuel
hal.structure.identifierMicro et Nanomédecines Translationnelles [MINT]
dc.contributor.authorSIMONSSON, Carl
hal.structure.identifierMicro et Nanomédecines Translationnelles [MINT]
dc.contributor.authorWANG, Sébastien
hal.structure.identifierInstitut des Molécules et Matériaux du Mans [IMMM]
dc.contributor.authorCOLOMBANI, Olivier
hal.structure.identifierMicro et Nanomédecines Translationnelles [MINT]
dc.contributor.authorCALVIGNAC, Brice
dc.date.issued2022-09
dc.identifier.issn0896-8446
dc.description.abstractEnVaterite, a polymorphic form of precipitated calcium carbonate, is an interesting material for various applications such as formulation of drug delivery systems due to its nanoporous structure. One of the carbonation processes to obtain nanostructured microspheres of vaterite consists in mixing an aqueous calcium phase with a supercritical CO2 phase, resulting in a heterogeneous dispersion. In this study, a continuous microfluidic method has been evaluated to produce monodisperse porous vaterite microparticles. A high-pressure microfluidic set-up has been developed, revealing that the dimensions and the dispersity of the CaCO3 particles are not affected by pressure but can be decreased by increasing the flow rate of the scCO2 and aqueous phases or addition of polymers in the aqueous phase. These observations were shown not to be related to the degree of dispersion of each phase within the microfluidic channel but to the interaction of the polymer with the CaCO3 particles and to the depressurization step at the end of the channel.
dc.language.isoen
dc.publisherElsevier
dc.subject.envaterite
dc.subject.encalcium carbonate
dc.subject.ensupercritical carbon dioxide
dc.subject.enmicrofluidics
dc.subject.enpolymer
dc.subject.enpolydimethyl siloxane
dc.title.enReactive precipitation of vaterite calcium carbonate microspheres in supercritical carbon dioxide-water dispersion by microfluidics
dc.typeArticle de revue
dc.identifier.doi10.1016/j.supflu.2022.105678
dc.subject.halChimie
bordeaux.journalJournal of Supercritical Fluids
bordeaux.page105678
bordeaux.volume188
bordeaux.peerReviewedoui
hal.identifierhal-03737443
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03737443v1
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