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PEO coated magnetic nanoparticles for biomedical application

hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorAQIL, Abdelhafid
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorVASSEUR, S.
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDUGUET, E.
hal.structure.identifierIngénierie de la vectorisation particulaire
dc.contributor.authorPASSIRANI, Catherine
hal.structure.identifierIngénierie de la vectorisation particulaire
dc.contributor.authorBENOÎT, Jean-Pierre
hal.structure.identifierNMR and Molecular Imaging Laboratory
dc.contributor.authorROCH, A.
hal.structure.identifierNMR and Molecular Imaging Laboratory
dc.contributor.authorMÜLLER, Robert
hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorJÉRÔME, Robert
hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorJÉRÔME, Christine
dc.date.issued2008-10
dc.identifier.issn0014-3057
dc.description.abstractEnThis paper reports on the preparation, characterization and stealthiness of superparamagnetic nanoparticles (magnetite Fe3O4) with a 5 nm diameter and stabilized in water (pH > 6.5) by a shell of water-soluble poly(ethylene oxide) (PEO) chains. Two types of diblock copolymers, i.e., poly(acrylic acid)-b-poly(ethylene oxide), PAA-PEO, and poly(acrylic acid)-b-poly(acrylate methoxy poly(ethyleneoxide)), PAA-PAMPEO, were prepared as stabilizers with different compositions and molecular weights. At pH > 6.5, the negatively ionized PAA block interacts strongly with the positively-charged nanoparticles, thus playing the role of an anchoring block. Aggregates of coated nanoparticles were actually observed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The hydrodynamic diameter was in the 50-100 nm range and the aggregation number (number of nanoparticles per aggregate) was lying between several tens and hundred. Moreover, the stealthiness of these aggregates was assessed "in vitro" by the hemolytic CH50 test. No response of the complement system was observed, such that biomedical applications can be envisioned for these magnetic nanoparticles. Preliminary experiments of magnetic heating (10 kA/m; 108 kHz) were performed and specific absorption rate varied from 2 to 13 W/g(Fe).
dc.language.isoen
dc.publisherElsevier
dc.subject.enMagnetic nanoparticles RAFT polymerization Hyperthermia Stealth behavior
dc.typeArticle de revue
dc.identifier.doi10.1016/j.eurpolymj.2008.07.011
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
bordeaux.journalEuropean Polymer Journal
bordeaux.page3191-3199
bordeaux.volume44
bordeaux.issue10
bordeaux.peerReviewedoui
hal.identifierinserm-00520136
hal.version1
hal.popularnon
hal.audienceInternationale
dc.title.itPEO coated magnetic nanoparticles for biomedical application
hal.origin.linkhttps://hal.archives-ouvertes.fr//inserm-00520136v1
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