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Multilamellar liposomes entrapping aminosilane-modified maghemite nanoparticles: "magnetonions".

hal.structure.identifierCentre de recherches Paul Pascal [CRPP]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorMEYRE, Marie-Edith
hal.structure.identifierCentre de recherches Paul Pascal [CRPP]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorCLÉRAC, Rodolphe
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMORNET, Stéphane
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDUGUET, Etienne
hal.structure.identifierCentre de recherches Paul Pascal [CRPP]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorDOLE, François
hal.structure.identifierCentre de recherches Paul Pascal [CRPP]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorNALLET, Frédéric
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLAMBERT, Olivier
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorTRÉPOUT, Sylvain
hal.structure.identifierCentre de recherches Paul Pascal [CRPP]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorFAURE, Chrystel
dc.date.issued2010
dc.identifier.issn1463-9076
dc.description.abstractEn4.6 nm-sized aminosilane-modified maghemite (γ-Fe(2)O(3)) nanoparticles (aMNPs) were synthesized and encapsulated into onion-type multilamellar vesicles of soybean phosphatidylcholine (90%mol) and monoolein (10%mol). The magnetic multilamellar vesicles were obtained by shearing lipids with an aqueous dispersion of the preformed aMNPs (ferrofluid). The influence of ferrofluid concentration on the stability of the constitutive lamellar phase and the resulting dispersed onions was analyzed by small-angle X-ray diffraction (SAXD) and cryo-TEM imaging, respectively. When [Fe(III)] <60 mM, stable, magnetic onions were produced with aMNPs inserted inside onion water compartments as isolated or aggregated particles. Encapsulation efficiencies were measured by EPR spectroscopy and magnetic measurements: much higher values (up to 75%) than unilamellar liposomes were found. The deduced aMNP-to-onion ratio increased with ferrofluid concentration before reaching a maximal value of ca. 45 as confirmed by cryo-TEM imaging. When [Fe(III)] >60 mM, uni- or oligolamellar vesicles in addition to onions formed, probably because of a two-phase separation between an aMNP-rich phase and an aMNP-containing lamellar phase as revealed by SAXD.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.typeArticle de revue
dc.identifier.doi10.1039/c0cp00231c
dc.subject.halChimie/Matériaux
bordeaux.journalPhysical Chemistry Chemical Physics
bordeaux.page12794-12801
bordeaux.volume12
bordeaux.issue39
bordeaux.peerReviewedoui
hal.identifierhal-00530393
hal.version1
hal.popularnon
hal.audienceInternationale
dc.title.itMultilamellar liposomes entrapping aminosilane-modified maghemite nanoparticles: "magnetonions".
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00530393v1
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