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High hydrostatic pressure treatment for the inactivation of Staphylococcus aureus in human blood plasma.

hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorRIVALAIN, Nolwennig
hal.structure.identifierUniversité Bordeaux Segalen - Bordeaux 2
dc.contributor.authorROQUAIN, Jean
hal.structure.identifierUniversité Bordeaux Segalen - Bordeaux 2
hal.structure.identifierEtablissement Français du Sang [EFS]
dc.contributor.authorBOIRON, Jean-Michel
hal.structure.identifierEtablissement Français du Sang [EFS]
dc.contributor.authorMAUREL, Jean-Paul
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLARGETEAU, Alain
hal.structure.identifierEtablissement Français du Sang [EFS]
dc.contributor.authorIVANOVIC, Zoran
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDEMAZEAU, Gérard
dc.date.issued2012
dc.identifier.issn1871-6784
dc.description.abstractEnFor the past 30years, pressure inactivation of microorganisms has been developed in biosciences, in particular for foods and more recently for biological products, including pharmaceutical ones. In many past studies, the effect of high hydrostatic pressure (HHP) processes on pathogens focused mainly on the effect of an increase of the pressure value. To assure the safety of pharmaceutical products containing fragile therapeutic components, development of new decontamination processes at the lowest pressure value is needed to maintain their therapeutic properties. The aim of this study was therefore to evaluate the impact of the process parameters characterizing high-pressure treatments [such as the pressurization rate (PR) and the application mode (AM)] on the inactivation of pathogens, in particular to determine how these parameters values could help decrease the pressure value necessary to reach the same inactivation level. The effect of these physical parameters was evaluated on the inactivation of Staphylococcus aureus ATCC 6538 which is an opportunistic pathogen of important relevance in the medical, pharmaceutical and food domains. Human blood plasma was chosen as the suspension medium because of its physiological importance in the transfusion field. It was shown that the optimization of all the selected parameters could lead to a high inactivation level (≈5log(10) decrease of the initial bacterial load) at a pressure level as low as 200MPa, underlining some synergistic effects among these parameters. Complete inactivation of the initial bacterial population was achieved for the following conditions: PR=50MPas(-1), AM=5×2min, T≈-5°C and P=300MPa.
dc.language.isoen
dc.publisherElsevier
dc.subject.enPlasma
dc.subject.enHigh pressure
dc.subject.enStaphylococcus aureus
dc.subject.enBlood
dc.title.enHigh hydrostatic pressure treatment for the inactivation of Staphylococcus aureus in human blood plasma.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.nbt.2011.10.003
dc.subject.halChimie/Matériaux
bordeaux.journalNew Biotechnology
bordeaux.page409-414
bordeaux.volume29
bordeaux.issue3
bordeaux.peerReviewedoui
hal.identifierhal-00670186
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00670186v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=New%20Biotechnology&rft.date=2012&rft.volume=29&rft.issue=3&rft.spage=409-414&rft.epage=409-414&rft.eissn=1871-6784&rft.issn=1871-6784&rft.au=RIVALAIN,%20Nolwennig&ROQUAIN,%20Jean&BOIRON,%20Jean-Michel&MAUREL,%20Jean-Paul&LARGETEAU,%20Alain&rft.genre=article


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