MILO SEVIC, Irena; GUILLOT, Samuel; TADIC, Marin; DUTTINE, Mathieu; DUGUET, Etienne; PIERZCHALA, Katarzyna; SIENKIEWICZ, Andrzej; FORR O, L Aszl O; SABOUNGI, Marie-Louise

doi:10.1063/1.4862811

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MILO SEVIC, Irena
Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques [CSPBAT]

GUILLOT, Samuel
Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques [CSPBAT]

TADIC, Marin
Vinča Institute of Nuclear Sciences

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Applied Physics Letters. 2014, vol. 104, n° 4, p. 043701

American Institute of Physics

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We have investigated drug loading and release from thermosensitive gel emulsions with external triggering by an alternating magnetic field (AMF) for on-demand drug delivery. Superparamagnetic iron oxide nanoparticles dispersed in gel emulsions were used to study the loading and release capabilities, with the stable nitroxide radical 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) serving as the model drug. AMF activation gave similar results to temperature activation in a water bath at 37 C, showing that the principal effect of the AMF is a temperature increase without burst release. These results suggest that the system could play an important role in the development of advanced drug delivery.< Réduire

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Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel

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