A New Rise of Non-Human Primate Models of Synucleinopathies
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | TEIL, Margaux | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | AROTCARENA, Marie Laure | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | DEHAY, Benjamin | |
| dc.date.accessioned | 2022-10-10T12:08:34Z | |
| dc.date.available | 2022-10-10T12:08:34Z | |
| dc.date.issued | 2021-03-09 | |
| dc.identifier.issn | 2227-9059 | en_US |
| dc.identifier.uri | oai:crossref.org:10.3390/biomedicines9030272 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/148372 | |
| dc.description.abstractEn | Synucleinopathies are neurodegenerative diseases characterized by the presence of α-synuclein-positive intracytoplasmic inclusions in the central nervous system. Multiple experimental models have been extensively used to understand better the mechanisms involved in the pathogenesis of synucleinopathy. Non-human primate (NHP) models are of interest in neurodegenerative diseases as they constitute the highest relevant preclinical model in translational research. They also contribute to bringing new insights into synucleinopathy’s pathogenicity and help in the quest and validation of therapeutical strategies. Here, we reviewed the different NHP models that have recapitulated key characteristics of synucleinopathy, and we aimed to highlight the contribution of NHP in mechanistic and translational approaches for synucleinopathies. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.source | crossref | |
| dc.subject.en | Non-human primates | |
| dc.subject.en | Synucleinopathy | |
| dc.subject.en | Neurodegeneration | |
| dc.subject.en | α-synuclein | |
| dc.subject.en | Animal model | |
| dc.title.en | A New Rise of Non-Human Primate Models of Synucleinopathies | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/biomedicines9030272 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| dc.identifier.pubmed | 33803341 | en_US |
| bordeaux.journal | Biomedicines | en_US |
| bordeaux.volume | 9 | en_US |
| bordeaux.hal.laboratories | Institut des Maladies Neurodégénératives (IMN) - UMR 5293 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | dissemin | |
| hal.identifier | inserm-03183606 | |
| hal.version | 1 | |
| hal.export | false | |
| workflow.import.source | dissemin | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomedicines&rft.date=2021-03-09&rft.volume=9&rft.issue=3&rft.eissn=2227-9059&rft.issn=2227-9059&rft.au=TEIL,%20Margaux&AROTCARENA,%20Marie%20Laure&DEHAY,%20Benjamin&rft.genre=article |
