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A comprehensive analysis of excess depressive disorder in women and men living with HIV in France compared to the general population

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHEMAR, Victor
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHESSAMFAR, Mojgan
dc.contributor.authorNEAU, Didier
dc.contributor.authorVAREIL, Marc-Olivier
dc.contributor.authorROUANES, Nicolas
dc.contributor.authorLAZARO, Estibaliz
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorDUFFAU, Pierre
dc.contributor.authorCAZANAVE, Charles
dc.contributor.authorRISPAL, Patrick
dc.contributor.authorGABORIEAU, Valerie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLELEUX, Olivier
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBARGER, Diana
dc.date.accessioned2022-10-03T09:28:42Z
dc.date.available2022-10-03T09:28:42Z
dc.date.issued2022-04-16
dc.identifier.issn2045-2322en_US
dc.identifier.urioai:crossref.org:10.1038/s41598-022-10263-3
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/148341
dc.description.abstractEnAbstractWe aimed to estimate the prevalence of depressive disorder in people living with HIV (PLWH) and evaluate its association with non-HIV-specific and HIV-specific factors in PLWH and in PLWH compared to the general population (GP). We used cross-sectional data from the QuAliV study, conducted within the ANRS-CO3 Aquitaine-AQUIVIH-NA cohort of PLWH in Nouvelle-Aquitaine (2018–2020), and a nationally-representative survey in the GP (EHIS-ESPS, 2014–2015), we included all participants aged ≥ 18 years old who had completed the Patient Health Questionnaire-8 (PHQ-8). Depressive disorder was defined as Patient Health Questionnaire-8 score greater or equal to 10. Its association with non-HIV-specific (demographic, socio-economic, behavioral, health status), HIV-specific factors (immuno-viral markers, antiretrovirals, level of perceived HIV-stigma), and HIV-status was assessed using Poisson regression models with robust variance in women and men separately. We included 914 PLWH (683 men/231 women). More than one in five PLWH had depressive disorder. It was strongly associated with being younger and experiencing severe pain in both sexes. Unemployment in women, being single, and lack of family ties in men were also associated with depressive disorder. More than 30% of our sample reported HIV-stigma, with a dose–response relationship between level of perceived HIV-stigma and depressive disorder. The crude prevalence of depressive disorder was 2.49 (95%CI 1.92–3.22) and 4.20 (95%CI 3.48–5.05) times higher in women and men living with HIV respectively compared to GP counterparts and 1.46 (95%CI 1.09–1.95) and 2.45 (95%CI 1.93–3.09) times higher after adjustment for non-HIV specific factors. The adjusted prevalence ratio of depressive disorder was not significantly different in HIV-stigma free women, but remained twice as high in HIV-stigma free men. The prevalence of depressive disorder compared to the GP tended to decrease with age in PLWH. Excess depressive disorder remains a major concern in PLWH. Our findings reaffirm the importance of regular screening. Tackling social inequalities and HIV-stigma should be prioritized to ensure that PLWH achieve good mental as well as physical health outcomes.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.sourcecrossref
dc.title.enA comprehensive analysis of excess depressive disorder in women and men living with HIV in France compared to the general population
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41598-022-10263-3en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35430622en_US
bordeaux.journalScientific Reportsen_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamMORPH3EUSen_US
bordeaux.teamEMOSen_US
bordeaux.teamSISTM_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
bordeaux.import.sourcedissemin
hal.identifierhal-03794402
hal.version1
hal.date.transferred2022-10-03T09:28:46Z
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2022-04-16&rft.volume=12&rft.issue=1&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=HEMAR,%20Victor&HESSAMFAR,%20Mojgan&NEAU,%20Didier&VAREIL,%20Marc-Olivier&ROUANES,%20Nicolas&rft.genre=article


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