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dc.rights.licenseopenen_US
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorLEMERCIER, Clement E.
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorGARENNE, Andre
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPOULLETIER DE GANNES, Florence
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorEL KHOUEIRY, Corinne
dc.contributor.authorARNAUD‐CORMOS, Delia
dc.contributor.authorLEVEQUE, Philippe
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorLAGROYE, Isabelle
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPERCHERANCIER, Yann
IDREF: 075934140
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorLEWIS, Noelle
IDREF: 156821346
dc.date.accessioned2022-09-22T14:55:32Z
dc.date.available2022-09-22T14:55:32Z
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/148315
dc.description.abstractEnPrevious studies have shown that spontaneously active cultured networks of cortical neuron grown planar microelectrode arrays are sensitive to radiofrequency (RF) fields and exhibit an inhibitory response more pronounced as the exposure time and power increase. To better understand the mechanism behind the observed effects, we aimed at identifying similarities and differences between the inhibitory effect of RF fields (continuous wave, 1800 MHz) to the γ-aminobutyric acid type A (GABAA) receptor agonist muscimol (MU). Inhibition of the network bursting activity in response to RF exposure became apparent at an SAR level of 28.6 W/kg and co-occurred with an elevation of the culture medium temperature of ~1 °C. Exposure to RF fields preferentially inhibits bursting over spiking activity and exerts fewer constraints on neural network bursting synchrony, differentiating it from a pharmacological inhibition with MU. Network rebound excitation, a phenomenon relying on the intrinsic properties of cortical neurons, was observed following the removal of tonic hyperpolarization after washout of MU but not in response to cessation of RF exposure. This implies that hyperpolarization is not the main driving force mediating the inhibitory effects of RF fields. At the level of single neurons, network inhibition induced by MU and RF fields occurred with reduced action potential (AP) half-width. As changes in AP waveform strongly influence efficacy of synaptic transmission, the narrowing effect on AP seen under RF exposure might contribute to reducing network bursting activity. By pointing only to a partial overlap between the inhibitory hallmarks of these two forms of inhibition, our data suggest that the inhibitory mechanisms of the action of RF fields differ from the ones mediated by the activation of GABAA receptors.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.title.enComparative study between radiofrequency-induced and muscimol-induced inhibition of cul-3 tured networks of cortical neuron
dc.typeDocument de travail - Pré-publicationen_US
dc.identifier.doi10.1101/2022.04.05.487108en_US
dc.subject.halSciences de l'ingénieur [physics]/Traitement du signal et de l'imageen_US
dc.description.sponsorshipEuropeSemiconductor-based Ultrawideband Micromanipulation of CAncer STEm Cellsen_US
bordeaux.hal.laboratoriesLaboratoire d’Intégration du Matériau au Système (IMS) - UMR 5218en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
hal.identifierhal-03784141
hal.version1
hal.date.transferred2022-09-22T14:55:36Z
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=LEMERCIER,%20Clement%20E.&GARENNE,%20Andre&POULLETIER%20DE%20GANNES,%20Florence&EL%20KHOUEIRY,%20Corinne&ARNAUD%E2%80%90CORMOS,%20Delia&rft.genre=preprint


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