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dc.rights.licenseopenen_US
dc.contributor.authorORLACCHIO, Rosa
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPERCHERANCIER, Yann
IDREF: 075934140
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPOULLETIER DE GANNES, Florence
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorHURTIER, Annabelle
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorLAGROYE, Isabelle
dc.contributor.authorLEVEQUE, Philippe
dc.contributor.authorARNAUD‐CORMOS, Delia
dc.date.accessioned2022-08-26T10:21:41Z
dc.date.available2022-08-26T10:21:41Z
dc.date.issued2022-04-29
dc.identifier.issn0197-8462en_US
dc.identifier.urioai:crossref.org:10.1002/bem.22403
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140598
dc.description.abstractEnThis study aims to analyze in real-time the potential modifications induced by low-level continuous-wave and Global System for Mobile Communications radiofrequency (RF) exposure at 1.8 GHz on brain activation in anesthetized mice. A specific in vivo experimental setup consisting of a dipole antenna for the local exposure of the brain was fully characterized. A unique neuroimaging technique based on a functional ultrasound (fUS) probe was used to observe the areas of mice brain activation simultaneously to the RF exposure with unprecedented spatial and temporal resolution (~100 μm, 1 ms) following manual whisker stimulation using a brush. Numerical and experimental dosimetry was carried out to characterize the exposure and to guarantee the validity of the biological results. Our results show that the fUS probe can be efficiently used during in vivo exposure without interference with the dipole. In addition, we conclude that exposure to brain-averaged specific absorption rate levels of 2 and 6 W/kg does not introduce significant changes in the time course of the evoked fUS response in the left barrel field cortex. The proposed technique represents a valuable instrument for providing new insights into the possible effects induced on brain activation under RF exposure. For the first time, brain activity under mobile phone exposure was evaluated in vivo with fUS imaging, paving the way for more realistic exposure configurations, i.e. awake mice and new signals such as the 5 G networks. © 2022 Bioelectromagnetics Society.
dc.language.isoENen_US
dc.sourcecrossref
dc.subject.enbrain activation
dc.subject.endosimetry
dc.subject.enfunctional ultrasound (fUS) imaging
dc.subject.enin vivo exposure
dc.subject.enmobile phones
dc.title.enIn Vivo Functional Ultrasound (fUS) Real‐Time Imaging and Dosimetry of Mice Brain Under Radiofrequency Exposure
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/bem.22403en_US
dc.subject.halSciences de l'ingénieur [physics]/Traitement du signal et de l'imageen_US
bordeaux.journalBioelectromagneticsen_US
bordeaux.page257-267en_US
bordeaux.volume43en_US
bordeaux.hal.laboratoriesLaboratoire d’Intégration du Matériau au Système (IMS) - UMR 5218en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travailen_US
bordeaux.import.sourcedissemin
hal.identifierhal-03761697
hal.version1
hal.date.transferred2022-08-26T10:21:43Z
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bioelectromagnetics&rft.date=2022-04-29&rft.volume=43&rft.issue=4&rft.spage=257-267&rft.epage=257-267&rft.eissn=0197-8462&rft.issn=0197-8462&rft.au=ORLACCHIO,%20Rosa&PERCHERANCIER,%20Yann&POULLETIER%20DE%20GANNES,%20Florence&HURTIER,%20Annabelle&LAGROYE,%20Isabelle&rft.genre=article


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