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Anti-αIIb β3 immunization in Glanzmann thrombasthenia: review of literature and treatment recommendations
| dc.rights.license | open | en_US |
| dc.contributor.author | FIORE, Mathieu | |
| dc.contributor.author | D'OIRON, Roseline | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | PILLOIS, Xavier | |
| dc.contributor.author | ALESSI, Marie-Christine | |
| dc.date.accessioned | 2020-11-17T08:41:47Z | |
| dc.date.available | 2020-11-17T08:41:47Z | |
| dc.date.issued | 2018-04 | |
| dc.identifier.issn | 1365-2141 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/14048 | |
| dc.description.abstractEn | Glanzmann thrombasthenia (GT) is caused by inherited defects of the αIIb β3 platelet glycoprotein. This bleeding disorder can be treated with platelet transfusion therapy, but some patients will be immunized and begin to form anti-human leucocyte antigen (HLA) and/or anti-αIIb β3 antibodies. These antibodies can bind and interfere with the function of the transfused platelets, rendering treatment ineffective. However, platelet transfusion refractoriness attributable to HLA antibodies may be managed by the selection of compatible donors, although they are not always readily available, particularly in an emergency. Thus, anti-αIIb β3 antibodies represent one of the most severe complications in GT. Both genetic and environmental factors may contribute to the risk of anti-αIIb β3 development, but the underlying pathogenic mechanisms are still unknown. This review will summarize the current knowledge of the risk factors for development of anti-αIIb β3 antibodies in patients with GT and discuss how these findings may influence the clinical management of patients. | |
| dc.language.iso | EN | en_US |
| dc.subject | Article RECHERCHE | |
| dc.subject.en | Autoantibodies | |
| dc.subject.en | Glanzmann thrombasthenia | |
| dc.subject.en | Humans | |
| dc.subject.en | immunization | |
| dc.subject.en | Immunization | |
| dc.subject.en | platelet antibody | |
| dc.subject.en | Platelet Glycoprotein GPIIb-IIIa Complex | |
| dc.subject.en | Platelet Transfusion | |
| dc.subject.en | rFVIIa | |
| dc.subject.en | Risk Factors | |
| dc.subject.en | Thrombasthenia | |
| dc.subject.en | Transfusion Reaction | |
| dc.subject.en | αIIbβ3 | |
| dc.title.en | Anti-αIIb β3 immunization in Glanzmann thrombasthenia: review of literature and treatment recommendations | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/bjh.15087 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 29611179 | en_US |
| bordeaux.journal | British Journal of Haematology | en_US |
| bordeaux.page | 173–182 | en_US |
| bordeaux.volume | 181 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires - U1034 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=British%20Journal%20of%20Haematology&rft.date=2018-04&rft.volume=181&rft.issue=2&rft.spage=173%E2%80%93182&rft.epage=173%E2%80%93182&rft.eissn=1365-2141&rft.issn=1365-2141&rft.au=FIORE,%20Mathieu&D'OIRON,%20Roseline&PILLOIS,%20Xavier&ALESSI,%20Marie-Christine&rft.genre=article |
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