Afficher la notice abrégée

International electronic health record-derived post-acute sequelae profiles of COVID-19 patients

dc.rights.licenseopenen_US
dc.contributor.authorZHANG, Harrison G.
dc.contributor.authorDAGLIATI, Arianna
dc.contributor.authorSHAKERI HOSSEIN ABAD, Zahra
dc.contributor.authorXIONG, Xin
dc.contributor.authorBONZEL, Clara-Lea
dc.contributor.authorXIA, Zongqi
dc.contributor.authorTAN, Bryce W. Q.
dc.contributor.authorAVILLACH, Paul
dc.contributor.authorBRAT, Gabriel A.
dc.contributor.authorHONG, Chuan
dc.contributor.authorMORRIS, Michele
dc.contributor.authorVISWESWARAN, Shyam
dc.contributor.authorPATEL, Lav P.
dc.contributor.authorGUTIERREZ-SACRISTAN, Alba
dc.contributor.authorHANAUER, David A.
dc.contributor.authorHOLMES, John H.
dc.contributor.authorSAMAYAMUTHU, Malarkodi Jebathilagam
dc.contributor.authorBOURGEOIS, Florence T.
dc.contributor.authorL'YI, Sehi
dc.contributor.authorMAIDLOW, Sarah E.
dc.contributor.authorMOAL, Bertrand
dc.contributor.authorMURPHY, Shawn N.
dc.contributor.authorSTRASSER, Zachary H.
dc.contributor.authorNEURAZ, Antoine
dc.contributor.authorNGIAM, Kee Yuan
dc.contributor.authorLOH, Ne Hooi Will
dc.contributor.authorOMENN, Gilbert S.
dc.contributor.authorPRUNOTTO, Andrea
dc.contributor.authorDALVIN, Lauren A.
dc.contributor.authorKLANN, Jeffrey G.
dc.contributor.authorSCHUBERT, Petra
dc.contributor.authorVIDORRETA, Fernando J. Sanz
dc.contributor.authorBENOIT, Vincent
dc.contributor.authorVERDY, Guillaume
dc.contributor.authorKAVULURU, Ramakanth
dc.contributor.authorESTIRI, Hossein
dc.contributor.authorLUO, Yuan
dc.contributor.authorMALOVINI, Alberto
dc.contributor.authorTIBOLLO, Valentina
dc.contributor.authorBELLAZZI, Riccardo
dc.contributor.authorCHO, Kelly
dc.contributor.authorHO, Yuk-Lam
dc.contributor.authorTAN, Amelia L. M.
dc.contributor.authorTAN, Byorn W. L.
dc.contributor.authorGEHLENBORG, Nils
dc.contributor.authorLOZANO-ZAHONERO, Sara
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJOUHET, Vianney
dc.contributor.authorCHIOVATO, Luca
dc.contributor.authorARONOW, Bruce J.
dc.contributor.authorTOH, Emma M. S.
dc.contributor.authorWONG, Wei Gen Scott
dc.contributor.authorPIZZIMENTI, Sara
dc.contributor.authorWAGHOLIKAR, Kavishwar B
dc.contributor.authorBUCALO, Mauro
dc.contributor.authorCAI, Tianxi
dc.contributor.authorSOUTH, Andrew M.
dc.contributor.authorKOHANE, Isaac S.
dc.contributor.authorWEBER, Griffin M.
dc.date.accessioned2022-07-13T08:26:50Z
dc.date.available2022-07-13T08:26:50Z
dc.date.issued2022-06-29
dc.identifier.issn2398-6352en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140463
dc.description.abstractEnThe risk profiles of post-acute sequelae of COVID-19 (PASC) have not been well characterized in multi-national settings with appropriate controls. We leveraged electronic health record (EHR) data from 277 international hospitals representing 414,602 patients with COVID-19, 2.3 million control patients without COVID-19 in the inpatient and outpatient settings, and over 221 million diagnosis codes to systematically identify new-onset conditions enriched among patients with COVID-19 during the post-acute period. Compared to inpatient controls, inpatient COVID-19 cases were at significant risk for angina pectoris (RR 1.30, 95% CI 1.09-1.55), heart failure (RR 1.22, 95% CI 1.10-1.35), cognitive dysfunctions (RR 1.18, 95% CI 1.07-1.31), and fatigue (RR 1.18, 95% CI 1.07-1.30). Relative to outpatient controls, outpatient COVID-19 cases were at risk for pulmonary embolism (RR 2.10, 95% CI 1.58-2.76), venous embolism (RR 1.34, 95% CI 1.17-1.54), atrial fibrillation (RR 1.30, 95% CI 1.13-1.50), type 2 diabetes (RR 1.26, 95% CI 1.16-1.36) and vitamin D deficiency (RR 1.19, 95% CI 1.09-1.30). Outpatient COVID-19 cases were also at risk for loss of smell and taste (RR 2.42, 95% CI 1.90-3.06), inflammatory neuropathy (RR 1.66, 95% CI 1.21-2.27), and cognitive dysfunction (RR 1.18, 95% CI 1.04-1.33). The incidence of post-acute cardiovascular and pulmonary conditions decreased across time among inpatient cases while the incidence of cardiovascular, digestive, and metabolic conditions increased among outpatient cases. Our study, based on a federated international network, systematically identified robust conditions associated with PASC compared to control groups, underscoring the multifaceted cardiovascular and neurological phenotype profiles of PASC.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enInternational electronic health record-derived post-acute sequelae profiles of COVID-19 patients
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41746-022-00623-8en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35768548en_US
bordeaux.journalnpj Digital Medicineen_US
bordeaux.volume5en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue81en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamAHEAD_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03722096
hal.version1
hal.date.transferred2022-07-13T08:27:20Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=npj%20Digital%20Medicine&rft.date=2022-06-29&rft.volume=5&rft.issue=81&rft.eissn=2398-6352&rft.issn=2398-6352&rft.au=ZHANG,%20Harrison%20G.&DAGLIATI,%20Arianna&SHAKERI%20HOSSEIN%20ABAD,%20Zahra&XIONG,%20Xin&BONZEL,%20Clara-Lea&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
BPH_NPJDM_2022_Zhang.pdf
Taille:
2.095Mo
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée