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Scribble1/AP2 Complex Coordinates NMDA Receptor Endocytic Recycling

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPIGUEL, Nicolas H.
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorFIEVRE, Sabine
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBLANC, Jean-Michel
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorCARTA, Mario
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMOREAU, Maite M.
dc.contributor.authorMOUTIN, Enora
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPINHEIRO, Vera L.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMEDINA, Chantal
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorEZAN, Jerome
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLASVAUX, Lea
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLOLL, Francois
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDURAND, Christelle M.
dc.contributor.authorCHANG, Kai
dc.contributor.authorPETRALIA, Ronald S.
dc.contributor.authorWENTHOLD, Robert J.
dc.contributor.authorSTEPHENSON, F. Anne
dc.contributor.authorVUILLARD, Laurent
dc.contributor.authorDARBON, Herve
dc.contributor.authorPERROY, Julie
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorMULLE, Christophe
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMONTCOUQUIOL, Mireille
hal.structure.identifierInstitute of Neuroscience [Newcastle] [ION]
dc.contributor.authorRACCA, Claudia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSANS, Nathalie
dc.date.accessioned2022-07-13T07:32:00Z
dc.date.available2022-07-13T07:32:00Z
dc.date.issued2014-10-23
dc.identifier.issn2211-1247en_US
dc.identifier.urihttps://www.researchgate.net/publication/266952158_Scribble1AP2_Complex_Coordinates_NMDA_Receptor_Endocytic_Recycling
dc.identifier.urioai:researchgate.net:266952158
dc.identifier.urioai:crossref.org:10.1016/j.celrep.2014.09.017
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140453
dc.description.abstractEnThe appropriate trafficking of glutamate receptors to synapses is crucial for basic synaptic function and synaptic plasticity. It is now accepted that NMDA receptors (NMDARs) internalize and are recycled at the plasma membrane but also exchange between synaptic and extrasynaptic pools; these NMDAR properties are also key to governing synaptic plasticity. Scribble1 is a large PDZ protein required for synaptogenesis and synaptic plasticity. Herein, we show that the level of Scribble1 is regulated in an activity-dependent manner and that Scribble1 controls the number of NMDARs at the plasma membrane. Notably, Scribble1 prevents GluN2A subunits from undergoing lysosomal trafficking and degradation by increasing their recycling to the plasma membrane following NMDAR activation. Finally, we show that a specific YxxR motif on Scribble1 controls these mechanisms through a direct interaction with AP2. Altogether, our findings define a molecular mechanism to control the levels of synaptic NMDARs via Scribble1 complex signaling.
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.description.sponsorshipCaractérisations moléculaire et fonctionnelle de la protéine Scribble 1 au cours du développement du système nerveux central - ANR-07-NEUR-0031en_US
dc.description.sponsorshipSignalisation de la polarité cellulaire planaire dans la plasticité synaptique morphofonctionnelle des circuits hippocampiques - ANR-12-BSV4-0016en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.sourceresearchgate
dc.sourcecrossref
dc.title.enScribble1/AP2 Complex Coordinates NMDA Receptor Endocytic Recycling
dc.title.alternativeCell Rep.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.celrep.2014.09.017en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed25310985en_US
bordeaux.journalCell Reportsen_US
bordeaux.page712-727en_US
bordeaux.volume9en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDFaculty of Medical Sciences, Newcastle Universityen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2014-10-23&rft.volume=9&rft.issue=2&rft.spage=712-727&rft.epage=712-727&rft.eissn=2211-1247&rft.issn=2211-1247&rft.au=PIGUEL,%20Nicolas%20H.&FIEVRE,%20Sabine&BLANC,%20Jean-Michel&CARTA,%20Mario&MOREAU,%20Maite%20M.&rft.genre=article


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