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Key findings on bipolar disorders from the longitudinal FondaMental Advanced Center of Expertise-Bipolar Disorder (FACE-BD) cohort

dc.rights.licenseopenen_US
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorGODIN, Ophelia
dc.contributor.authorLLORCA, Pierre-Michel
dc.contributor.authorAUBIN, Valerie
dc.contributor.authorBELLIVIER, Frank
dc.contributor.authorBELZEAUX, Raoul
dc.contributor.authorCOURTET, Philippe
dc.contributor.authorCOSTAGLIOLA, Dominique
dc.contributor.authorDUBERTRET, Caroline
hal.structure.identifierLaboratoire de psychologie:Santé et qualité de vie
dc.contributor.authorM BAILARA, Katia
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorHENRY, Chantal
dc.contributor.authorLAOUAMRI, H.
dc.contributor.authorPASSERIEUX, Christine
dc.contributor.authorPELLETIER, Amandine
dc.contributor.authorPOLOSAN, Mircea
dc.contributor.authorROUX, P.
dc.contributor.authorSCHWAN, Raymund
dc.contributor.authorSAMALIN, Ludovic
dc.contributor.authorOLIE, Emilie
dc.contributor.authorETAIN, Bruno
dc.date.accessioned2022-07-08T13:04:26Z
dc.date.available2022-07-08T13:04:26Z
dc.date.issued2022-06-15
dc.identifier.issn0165-0327en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140412
dc.description.abstractEnBackground : The FACE-BD cohort is an observational cohort of individuals with bipolar disorders (BD) who benefited from a systematic evaluation with evidence-based treatment recommendations and who were followed-up every year for 3 years in France. The objectives were to describe the lifetime course of BD, associated psychiatric and somatic comorbidities, and cognition profile. This cohort aims to identify clinical/biological signatures of outcomes, trajectories of functioning and transition between clinical stages. This article summarizes 10 years of findings of the FACE-BD cohort. Method & results : We included 4422 individuals, all having a baseline assessment, among which 61.2% had at least one follow-up visit at either one, two or three years. A subsample of 1200 individuals had at least one biological sample (serum, plasma, DNA). Assessments include family history of psychiatric disorders, psychiatric diagnosis, current mood symptoms, functioning, hospitalizations, suicidal attempts, physical health, routine blood tests, treatment history, psychological dimensions, medico-economic data and a cognitive assessment. Studies from this cohort illustrate that individuals with BD display multiple coexistent psychiatric associated conditions including sleep disturbances, anxiety disorders, substance use disorders and suicide attempts as well as a high prevalence of metabolic syndrome. During follow-up, we observed a 55% reduction of the number of days of hospitalization and a significant improvement in functioning. Conclusions :The FACE-BD cohort provides a strong research infrastructure for clinical research in BD and has a unique position among international cohorts because of its comprehensive clinical assessment and sustainable funding from the French Ministry of Health.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.subject.enBipolar disorders
dc.subject.enCohort
dc.subject.enLongitudinal
dc.subject.enCourse
dc.subject.enBiomarkers
dc.subject.enEnvironment
dc.title.enKey findings on bipolar disorders from the longitudinal FondaMental Advanced Center of Expertise-Bipolar Disorder (FACE-BD) cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jad.2022.03.053en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.subject.halSciences de l'Homme et Société/Psychologieen_US
dc.identifier.pubmed35339569
bordeaux.journalJournal of Affective Disordersen_US
bordeaux.page149-156en_US
bordeaux.volume307en_US
bordeaux.hal.laboratoriesLaboratoire de psychologie (LabPsy) - EA4139en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDAssistance publique-Hôpitaux de Parisen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.identifierhal-03624967
hal.version1
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Affective%20Disorders&rft.date=2022-06-15&rft.volume=307&rft.spage=149-156&rft.epage=149-156&rft.eissn=0165-0327&rft.issn=0165-0327&rft.au=LEBOYER,%20Marion&GODIN,%20Ophelia&LLORCA,%20Pierre-Michel&AUBIN,%20Valerie&BELLIVIER,%20Frank&rft.genre=article


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