Risk factors for acquisition of OXA-48-producing Klebsiella pneumonia among contact patients: a multicentre study
| dc.rights.license | open | en_US |
| dc.contributor.author | HILLIQUIN, D. | |
| dc.contributor.author | LE GUERN, R. | |
| dc.contributor.author | THEPOT SEEGERS, V. | |
| dc.contributor.author | NEULIER, C. | |
| dc.contributor.author | LOMONT, A. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MARIE, Véronique | |
| dc.contributor.author | LEGEAY, C. | |
| dc.contributor.author | MERRER, J. | |
| dc.contributor.author | LEPELLETIER, D. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ROGUES, Anne-Marie | |
| dc.contributor.author | GRANDBASTIEN, B. | |
| dc.contributor.author | LUCET, J. C. | |
| dc.contributor.author | ZAHAR, J. R. | |
| dc.date.accessioned | 2020-11-16T14:41:50Z | |
| dc.date.available | 2020-11-16T14:41:50Z | |
| dc.date.issued | 2018-03 | |
| dc.identifier.issn | 1532-2939 (Electronic) 0195-6701 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/14035 | |
| dc.description.abstractEn | Cohorting carbapenemase-producing Enterobacteriaceae (CPE) carriers during hospitalisation limits the in hospital spreading. Our objective was to identify risk factors for CPE acquisition among contacts of an index patient in non-cohorted populations. A multicentre retrospective matched case-control study was conducted in five hospitals. Each contact patient (case) who acquired Klebsiella pneumoniae OXA-48 from an index patient was compared to three contact (controls) with the same index patients matched with hospitalization in the same unit and similar exposure-times. Fifty-one secondary cases and 131 controls were included. By univariate analysis exposure time (OR=1.06; 95% CI = 1.02 - 1.1; p = 0.006), concomitant infection at admission (OR=3.23; 95% CI = 1.42 - 7.35; p = 0.005), antimicrobial therapy within the last month before hospitalization (OR=2.88; 95% CI = 1.34- 6.2; p = 0.007), antimicrobial therapy during the exposure-time (OR=5.36; 95% CI = 2.28 - 12.6; p < 0.001), use of at least one invasive procedure (OR=2.99; 95% CI = 1.25 - 7.15; p = 0.014), number of invasive procedure (OR=1.52; 95%CI = 1.05 - 2.19; p=0.025), and the geographical proximity (OR=2.84; 95% CI = 1.15 - 7.00; p = 0.023) were associated with CPE acquisition. By multivariate analysis, antimicrobial therapy during the exposure-time (OR=6.36; 95% CI = 2.46 - 16.44; p < 0.001), at least one invasive procedure (OR=2.92; 95%CI=1.04-8.17; p=0.041), and geographical proximity (OR=3.69; 95% CI = 1.15 - 11.86; p = 0.028) were associated with acquisition. In this study, geographical proximity, invasive procedure and antimicrobial therapy during exposure-time were significantly associated with KP-OXA-48 acquisition. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | PharmacoEpi-Drugs | |
| dc.title.en | Risk factors for acquisition of OXA-48-producing Klebsiella pneumonia among contact patients: a multicentre study | |
| dc.title.alternative | J Hosp Infect | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jhin.2017.08.024 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 28882642 | en_US |
| bordeaux.journal | The Journal of hospital infection | en_US |
| bordeaux.page | 253-259 | en_US |
| bordeaux.volume | 98 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | PharmacoEpi-Drugs | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The%20Journal%20of%20hospital%20infection&rft.date=2018-03&rft.volume=98&rft.issue=3&rft.spage=253-259&rft.epage=253-259&rft.eissn=1532-2939%20(Electronic)%200195-6701%20(Linking)&rft.issn=1532-2939%20(Electronic)%200195-6701%20(Linking)&rft.au=HILLIQUIN,%20D.&LE%20GUERN,%20R.&THEPOT%20SEEGERS,%20V.&NEULIER,%20C.&LOMONT,%20A.&rft.genre=article |
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