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Revisiting planar cell polarity in the inner ear
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | EZAN, Jerome | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MONTCOUQUIOL, Mireille | |
| dc.date.accessioned | 2022-06-30T13:45:54Z | |
| dc.date.available | 2022-06-30T13:45:54Z | |
| dc.date.issued | 2013-05-01 | |
| dc.identifier.issn | 1084-9521 | en_US |
| dc.identifier.uri | oai:crossref.org:10.1016/j.semcdb.2013.03.012 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140347 | |
| dc.description.abstractEn | Since the first implication of the core planar cell polarity (PCP) pathway in stereocilia orientation of sensory hair cells in the mammalian cochlea, much has been written about this subject, in terms of understanding how this pathway can shape the mammalian hair cells and using the inner ear as a model system to understand mammalian PCP signaling. However, many conflicting results have arisen, leading to puzzling questions regarding the actual mechanism and roles of core PCP signaling in mammals and invertebrates. In this review, we summarize our current knowledge on the establishment of PCP during inner ear development and revisit the contrast between wing epithelial cells in Drosophila melanogaster and sensory epithelia in the mammalian cochlea. Notably, we focus on similarities and differences in the asymmetric distribution of core PCP proteins in the context of cell autonomous versus non-autonomous role of PCP signaling in the two systems. Additionally, we address the relationship between the kinocil- ium position and PCP in cochlear hair cells and increasing results suggest an alternate cell autonomous pathway in regulating PCP in sensory hair cells. | |
| dc.description.sponsorship | Caractérisation moléculaire et fonctionnelle de vangl2 et de ses partenaires chez le mammifère - ANR-08-MNPS-0040 | en_US |
| dc.language.iso | EN | en_US |
| dc.source | crossref | |
| dc.subject.en | Planar cell polarity | |
| dc.subject.en | Polarity | |
| dc.subject.en | Vangl2 | |
| dc.subject.en | Cochlea | |
| dc.subject.en | Vestibule | |
| dc.subject.en | Asymmetry | |
| dc.subject.en | Cilium | |
| dc.subject.en | Orientation | |
| dc.title.en | Revisiting planar cell polarity in the inner ear | |
| dc.title.alternative | Semin Cell Dev Biol. | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.semcdb.2013.03.012 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | |
| dc.identifier.pubmed | 23562830 | en_US |
| bordeaux.journal | Seminars in Cell and Developmental Biology | en_US |
| bordeaux.page | 499-506 | en_US |
| bordeaux.volume | 24 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - UMR-S 1215 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.import.source | dissemin | |
| hal.identifier | hal-03781380 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-09-20T10:03:46Z | |
| hal.export | true | |
| workflow.import.source | dissemin | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Seminars%20in%20Cell%20and%20Developmental%20Biology&rft.date=2013-05-01&rft.volume=24&rft.issue=5&rft.spage=499-506&rft.epage=499-506&rft.eissn=1084-9521&rft.issn=1084-9521&rft.au=EZAN,%20Jerome&MONTCOUQUIOL,%20Mireille&rft.genre=article |
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