Afficher la notice abrégée

The Planar Polarity Protein Scribble1 Is Essential for Neuronal Plasticity and Brain Function

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U862
dc.contributor.authorMOREAU, Maite
IDREF: 11490247X
hal.structure.identifierNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U862
dc.contributor.authorPIGUEL, Nicolas
hal.structure.identifierNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U862
dc.contributor.authorPAPOUIN, Thomas
hal.structure.identifierNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U862
dc.contributor.authorKOEHL, Muriel
hal.structure.identifierNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U862
dc.contributor.authorDURAND, Christelle M.
hal.structure.identifierUniversity of Connecticut [UCONN]
dc.contributor.authorRUBIO, Maria E.
hal.structure.identifierNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U862
dc.contributor.authorLOLL, François
hal.structure.identifierNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U862
dc.contributor.authorRICHARD, Elodie M.
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorMAZZOCCO, Claire
hal.structure.identifierInstitute of Neuroscience [Newcastle] [ION]
dc.contributor.authorRACCA, Claudia
hal.structure.identifierNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U862
dc.contributor.authorOLIET, Stéphane
hal.structure.identifierNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U862
dc.contributor.authorNORA ABROUS, D.
hal.structure.identifierNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U862
dc.contributor.authorMONTCOUQUIOL, Mireille
hal.structure.identifierNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U862
dc.contributor.authorSANS, Nathalie
dc.date.accessioned2022-06-30T10:01:57Z
dc.date.available2022-06-30T10:01:57Z
dc.date.issued2010-07-21
dc.identifier.issn1529-2401en_US
dc.identifier.urihttps://www.researchgate.net/publication/45365861_The_Planar_Polarity_Protein_Scribble1_Is_Essential_for_Neuronal_Plasticity_and_Brain_Function
dc.identifier.urioai:researchgate.net:45365861
dc.identifier.urioai:crossref.org:10.1523/jneurosci.6007-09.2010
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140344
dc.description.abstractEnScribble (Scrib) is a key regulator of apicobasal polarity, presynaptic architecture, and short-term synaptic plasticity in Drosophila. In mammals, its homolog Scrib1 has been implicated in cancer, neural tube closure, and planar cell polarity (PCP), but its specific role in the developing and adult nervous system is unclear. Here, we used the circletail mutant, a mouse model for PCP defects, to show that Scrib1 is located in spines where it influences actin cytoskeleton and spine morphing. In the hippocampus of these mutants, we observed an increased synapse pruning associated with an increased number of enlarged spines and postsynaptic density, and a decreased number of perforated synapses. This phenotype was associated with a mislocalization of the signaling pathway downstream of Scrib1, leading to an overall activation of Rac1 and defects in actin dynamic reorganization. Finally, Scrib1-deficient mice exhibit enhanced learning and memory abilities and impaired social behavior, two features relevant to autistic spectrum disorders. Our data identify Scrib1 as a crucial regulator of brain development and spine morphology, and suggest that Scrib1(crc/+) mice might be a model for studying synaptic dysfunction and human psychiatric disorders.
dc.language.isoENen_US
dc.sourceresearchgate
dc.sourcecrossref
dc.title.enThe Planar Polarity Protein Scribble1 Is Essential for Neuronal Plasticity and Brain Function
dc.typeArticle de revueen_US
dc.identifier.doi10.1523/jneurosci.6007-09.2010en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.journalThe Journal of neuroscience : the official journal of the Society for Neuroscienceen_US
bordeaux.page9738-9752en_US
bordeaux.volume30en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue29en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The%20Journal%20of%20neuroscience%20:%20the%20official%20journal%20of%20the%20Society%20for%20Neuroscience&rft.date=2010-07-21&rft.volume=30&rft.issue=29&rft.spage=9738-9752&rft.epage=9738-9752&rft.eissn=1529-2401&rft.issn=1529-2401&rft.au=MOREAU,%20Maite&PIGUEL,%20Nicolas&PAPOUIN,%20Thomas&KOEHL,%20Muriel&DURAND,%20Christelle%20M.&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
MAGENDIE_JNeuroscie_2010_Moreau.pdf
Taille:
4.805Mo
Format:
PDF
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée