Scribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MOREAU, Maite M. | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | PIETROPAOLO, Susanna | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | EZAN, Jerome | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | ROBERT, Benjamin J. A. | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | MIRAUX, Sylvain
IDREF: 150967047 | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MAITRE, Marlene | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | CHO, Yoon | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | CRUSIO, Wim E. | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MONTCOUQUIOL, Mireille | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | SANS, Nathalie | |
| dc.date.accessioned | 2022-06-30T09:26:11Z | |
| dc.date.available | 2022-06-30T09:26:11Z | |
| dc.date.issued | 2022-05-10 | |
| dc.identifier.issn | 2073-4409 | en_US |
| dc.identifier.uri | oai:crossref.org:10.3390/cells11101601 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140342 | |
| dc.description.abstractEn | Social behavior is a basic domain affected by several neurodevelopmental disorders, including ASD and a heterogeneous set of neuropsychiatric disorders. The SCRIB gene that codes for the polarity protein SCRIBBLE has been identified as a risk gene for spina bifida, the most common type of neural tube defect, found at high frequencies in autistic patients, as well as other congenital anomalies. The deletions and mutations of the 8q24.3 region encompassing SCRIB are also associated with multisyndromic and rare disorders. Nonetheless, the potential link between SCRIB and relevant social phenotypes has not been fully investigated. Hence, we show that Scribcrc/+ mice, carrying a mutated version of Scrib, displayed reduced social motivation behavior and social habituation, while other behavioral domains were unaltered. Social deficits were associated with the upregulation of ERK phosphorylation, together with increased c-Fos activity. Importantly, the social alterations were rescued by both direct and indirect pERK inhibition. These results support a link between polarity genes, social behaviors and hippocampal functionality and suggest a role for SCRIB in the etiopathology of neurodevelopmental disorders. Furthermore, our data demonstrate the crucial role of the MAPK/ERK signaling pathway in underlying social motivation behavior, thus supporting its relevance as a therapeutic target. | |
| dc.description.sponsorship | Codage de l'information sociale dans l'hippocampe et la synchronie des réseaux neuronaux dans l'autisme - ANR-13-SAMA-0012 | en_US |
| dc.description.sponsorship | Développment d'une infrastructure française distribuée coordonnée | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.source | crossref | |
| dc.subject | Humans | |
| dc.subject.en | Animals | |
| dc.subject.en | Intracellular Signaling Peptides and Proteins | |
| dc.subject.en | Genetics | |
| dc.subject.en | MAP Kinase Signaling System | |
| dc.subject.en | Mice | |
| dc.subject.en | Motivation | |
| dc.subject.en | Mutation | |
| dc.subject.en | Protein Serine-Threonine Kinases | |
| dc.subject.en | Metabolism | |
| dc.subject.en | Signal Transduction | |
| dc.subject.en | Social Behavior | |
| dc.title.en | Scribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/cells11101601 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 35626639 | en_US |
| bordeaux.journal | Cells | en_US |
| bordeaux.page | 1601 | en_US |
| bordeaux.volume | 11 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - UMR-S 1215 | en_US |
| bordeaux.issue | 10 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.import.source | dissemin | |
| hal.identifier | hal-03709848 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-06-30T09:26:22Z | |
| hal.export | true | |
| workflow.import.source | dissemin | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cells&rft.date=2022-05-10&rft.volume=11&rft.issue=10&rft.spage=1601&rft.epage=1601&rft.eissn=2073-4409&rft.issn=2073-4409&rft.au=MOREAU,%20Maite%20M.&PIETROPAOLO,%20Susanna&EZAN,%20Jerome&ROBERT,%20Benjamin%20J.%20A.&MIRAUX,%20Sylvain&rft.genre=article |
