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Normal-Appearing White Matter Deteriorates over the Year After an Ischemic Stroke and Is Associated with Global Cognition

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierCHU Bordeaux
dc.contributor.authorSAGNIER, Sharmila
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCATHELINE, Gwenaëlle
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorDILHARREGUY, Bixente
hal.structure.identifierCHU Bordeaux
dc.contributor.authorLINCK, Pierre-Antoine
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
hal.structure.identifierPatch-based processing for medical and natural images [PICTURA]
dc.contributor.authorCOUPÉ, Pierrick
hal.structure.identifierBeth Israel Deaconess Medical Center [Boston] [BIDMC]
dc.contributor.authorMUNSCH, Fanny
hal.structure.identifierCHU Bordeaux
dc.contributor.authorBIGOURDAN, Antoine
hal.structure.identifierCHU Bordeaux
dc.contributor.authorPOLI, Mathilde
hal.structure.identifierCHU Bordeaux
dc.contributor.authorDEBRUXELLES, Sabrina
hal.structure.identifierCHU Bordeaux
dc.contributor.authorRENOU, Pauline
hal.structure.identifierCHU Bordeaux
dc.contributor.authorOLINDO, Stéphane
hal.structure.identifierCHU Bordeaux
dc.contributor.authorROUANET, François
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorDOUSSET, Vincent
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorTOURDIAS, Thomas
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierCHU Bordeaux
dc.contributor.authorSIBON, Igor
dc.date.accessioned2022-06-28T08:12:24Z
dc.date.available2022-06-28T08:12:24Z
dc.date.issued2022-01-17
dc.identifier.issn1868-4483en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140316
dc.description.abstractEnNormal-appearing white matter (NAWM) is a hub of plasticity, but data relating to its influence on post-ischemic stroke (IS) outcome remain scarce. The aim of this study was to evaluate the relationship between NAWM integrity and cognitive outcome after an IS. A longitudinal study was conducted including supra-tentorial IS patients. A 3-Tesla brain MRI was performed at baseline and 1 year, allowing the analyses of mean fractional anisotropy (FA) and mean diffusivity (MD) in NAWM masks, along with the volume of white matter hyperintensities (WMH) and IS. A Montreal Cognitive Assessment (MoCA), an Isaacs set test, and a Zazzo's cancellation task were performed at baseline, 3 months and 1 year. Mixed models were built, followed by Tract-based Spatial Statistics (TBSS) analyses. Ninety-five patients were included in the analyses (38% women, median age 69 ± 20). FA significantly decreased, and MD significantly increased between baseline and 1 year, while cognitive scores improved. Patients who decreased their NAWM FA more over the year had a slower cognitive improvement on MoCA (β = - 0.11, p = 0.05). The TBSS analyses showed that patients who presented the highest decrease of FA in various tracts of white matter less improved their MoCA performances, regardless of WMH and IS volumes, demographic confounders, and clinical severity. NAWM integrity deteriorates over the year after an IS, and is associated with a cognitive recovery slowdown. The diffusion changes recorded here in patients starting with an early preserved white matter structure could have long term impact on cognition.
dc.description.sponsorshipTranslational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057en_US
dc.language.isoENen_US
dc.subject.enDiffusion tensor imaging
dc.subject.enLongitudinal
dc.subject.enPrognosis
dc.subject.enStroke
dc.title.enNormal-Appearing White Matter Deteriorates over the Year After an Ischemic Stroke and Is Associated with Global Cognition
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s12975-022-00988-8en_US
dc.subject.halInformatique [cs]/Imagerie médicaleen_US
bordeaux.journalTranslational stroke research./Transl Stroke Resen_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03651487
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational%20stroke%20research./Transl%20Stroke%20Res&rft.date=2022-01-17&rft.eissn=1868-4483&rft.issn=1868-4483&rft.au=SAGNIER,%20Sharmila&CATHELINE,%20Gwena%C3%ABlle&DILHARREGUY,%20Bixente&LINCK,%20Pierre-Antoine&COUP%C3%89,%20Pierrick&rft.genre=article


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