Assembly of Fluorescent Polymer Nanoparticles Using Different Microfluidic Mixers.
| dc.rights.license | embargo | en_US |
| hal.structure.identifier | Université de Strasbourg [UNISTRA] | |
| hal.structure.identifier | Laboratoire de Bioimagerie et Pathologies [LBP] | |
| dc.contributor.author | CHEN, Huaiyou | |
| hal.structure.identifier | Université de Strasbourg [UNISTRA] | |
| hal.structure.identifier | Laboratoire de Bioimagerie et Pathologies [LBP] | |
| dc.contributor.author | CELIK, Ali Emre | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | MUTSCHLER, Angela
IDREF: 224745379 | |
| hal.structure.identifier | Université de Strasbourg [UNISTRA] | |
| hal.structure.identifier | Laboratoire de Bioimagerie et Pathologies [LBP] | |
| dc.contributor.author | COMBES, Antoine | |
| hal.structure.identifier | Université de Strasbourg [UNISTRA] | |
| hal.structure.identifier | Laboratoire de Bioimagerie et Pathologies [LBP] | |
| dc.contributor.author | RUNSER, Anne | |
| hal.structure.identifier | Université de Strasbourg [UNISTRA] | |
| hal.structure.identifier | Laboratoire de Bioimagerie et Pathologies [LBP] | |
| dc.contributor.author | KLYMCHENKO, Andrey S | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sebastien | |
| hal.structure.identifier | Institut Charles Sadron [ICS] | |
| hal.structure.identifier | Université de Strasbourg [UNISTRA] | |
| dc.contributor.author | SERRA, Christophe A | |
| hal.structure.identifier | Université de Strasbourg [UNISTRA] | |
| hal.structure.identifier | Laboratoire de Bioimagerie et Pathologies [LBP] | |
| dc.contributor.author | REISCH, Andreas | |
| dc.date.accessioned | 2022-06-24T17:08:09Z | |
| dc.date.available | 2022-06-24T17:08:09Z | |
| dc.date.issued | 2022-06-22 | |
| dc.identifier.issn | 1520-5827 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140314 | |
| dc.description.abstractEn | Nanoprecipitation is a facile and efficient approach to the assembly of loaded polymer nanoparticles (NPs) for applications in bioimaging and targeted drug delivery. Their successful use in clinics requires reproducible and scalable synthesis, for which microfluidics appears as an attractive technique. However, in the case of nanoprecipitation, particle formation depends strongly on mixing. Here, we compare 5 different types of microfluidic mixers with respect to the formation and properties of poly(d-l-lactide--glycolide) (PLGA) and poly(methyl methacrylate) NPs loaded with a fluorescent dye salt: a cross-shaped mixer, a multilamination mixer, a split and recombine mixer, two herringbone mixers, and two impact jet mixers. Size and fluorescence properties of the NPs obtained with these mixers are evaluated. All mixers, except the cross-shaped one, yield NPs at least as small and fluorescent as those obtained manually. Notably in the case of impact jet mixers operated at high flow speeds, the size of the NPs could be strongly reduced from >50 nm down to 70%. These results show the importance of precisely controlling the assembly conditions for loaded polymer NPs. The present work further provides guidance for choosing the optimal microfluidic setup for production of nanomaterials for biomedical applications. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
| dc.subject | Nanoprecipitation | |
| dc.subject | Size control | |
| dc.subject.en | Microfluidics | |
| dc.subject.en | Polymer nanoparticles | |
| dc.subject.en | Fluorescent nanoparticles | |
| dc.title.en | Assembly of Fluorescent Polymer Nanoparticles Using Different Microfluidic Mixers. | |
| dc.title.alternative | Langmuir | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1021/acs.langmuir.2c00534 | en_US |
| dc.subject.hal | Chimie/Polymères | en_US |
| dc.identifier.pubmed | 35731957 | en_US |
| bordeaux.journal | Langmuir | en_US |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03704362 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-06-24T17:08:18Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | CC BY-NC-SA | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Langmuir&rft.date=2022-06-22&rft.eissn=1520-5827&rft.issn=1520-5827&rft.au=CHEN,%20Huaiyou&CELIK,%20Ali%20Emre&MUTSCHLER,%20Angela&COMBES,%20Antoine&RUNSER,%20Anne&rft.genre=article |
