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Risk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGULMEZ, Sinem
dc.contributor.authorUNAL, U. S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLASSALLE, Regis
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHARTIER, Anaïs
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGROLLEAU, Adeline
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOORE, Nicholas
dc.date.accessioned2020-11-16T13:17:36Z
dc.date.available2020-11-16T13:17:36Z
dc.date.issued2018-11
dc.identifier.issn1099-1557 (Electronic) 1053-8569 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/14030
dc.description.abstractEnPURPOSE: The SALT study found similar per-user risks of acute liver failure (ALF) leading to transplantation (ALFT) between NSAIDs and a threefold higher risk in nonoverdose paracetamol (NOP) users. The objective of EPIHAM was to identify the risks of hospital admission for acute liver injury (ALI) associated with NSAIDs and NOP. METHODS: Case-population study in the 1/97 sample of the French population claims database. Acute liver injury was identified from hospital discharge summaries, from 2009 to 2013. Exposure for cases was dispensing of NSAID or NOP resulting in exposure within 30 days before admission. Population exposure was the number of patients using the drugs over the study timeframe and total number of DDD dispensed. RESULTS: Of 63 cases of ALI, 13 had been exposed to NSAIDs and 24 to NOP. Events per million DDD (95% CI) ranged from 0.46 (0.09-1.34) (ketoprofen) to 1.43 (0.04-7.97) (diclofenac combinations), 0.43 (0.23-0.73) all NSAIDs combined, 0.58 (0.37-0.86) for NOP. There was no association with average duration of treatment. Per patient risk ranged from 19.5 (5.31-49.9) (ibuprofen) per million users to 37.2 (19.8-63.6) all NSAIDs combined, 58.0 (37.2-86.3) for NOP. There was a linear relationship between average treatment duration and per-user risk (R(2) = 0.51, P < .05 for NSAIDs, R(2) = 0.97, P < .01 for NOP). CONCLUSIONS: Risk of hospital admission for ALI with NSAIDs and NOP was similar and indicative of a dose and duration-related effect (pharmacological) effect. Acute liver injury rates were not predictive of ALFT risk.
dc.language.isoENen_US
dc.subject.enPharmacoEpi-Drugs
dc.subject.enCIC1401
dc.title.enRisk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study
dc.title.alternativePharmacoepidemiol Drug Safen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/pds.4640en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30112779en_US
bordeaux.journalPharmacoepidemiology and drug safetyen_US
bordeaux.page1174-1181en_US
bordeaux.volume27en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.teamCIC1401en_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Pharmacoepidemiology%20and%20drug%20safety&amp;rft.date=2018-11&amp;rft.volume=27&amp;rft.issue=11&amp;rft.spage=1174-1181&amp;rft.epage=1174-1181&amp;rft.eissn=1099-1557%20(Electronic)%201053-8569%20(Linking)&amp;rft.issn=1099-1557%20(Electronic)%201053-8569%20(Linking)&amp;rft.au=GULMEZ,%20Sinem&amp;UNAL,%20U.%20S.&amp;LASSALLE,%20Regis&amp;CHARTIER,%20Ana%C3%AFs&amp;GROLLEAU,%20Adeline&amp;rft.genre=article


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