Afficher la notice abrégée

Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRASSET, Leslie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST-LIMA, Cecile
dc.contributor.authorMANGIN, Jean-Francois
dc.contributor.authorHABERT, Marie-Odile
dc.contributor.authorDUBOIS, Bruno
dc.contributor.authorPAQUET, Claire
dc.contributor.authorHANON, Olivier
dc.contributor.authorGABELLE, Audrey
dc.contributor.authorCECCALDI, Mathieu
dc.contributor.authorANNWEILER, Cedric
dc.contributor.authorDAVID, Renaud
dc.contributor.authorJONVEAUX, Therese
dc.contributor.authorBELIN, Catherine
dc.contributor.authorJULIAN, Adrien
dc.contributor.authorROUCH-LEROYER, Isabelle
dc.contributor.authorPARIENTE, Jeremie
dc.contributor.authorLOCATELLI, Maxime
dc.contributor.authorCHUPIN, Marie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorMEMENTO COHORT STUDY, Group
dc.date.accessioned2022-06-21T12:52:14Z
dc.date.available2022-06-21T12:52:14Z
dc.date.issued2022-05-18
dc.identifier.issn1758-9193 (Electronic)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140290
dc.description.abstractEnBACKGROUND: This work aimed to investigate the potential pathways involved in the association between social and lifestyle factors, biomarkers of Alzheimer's disease and related dementia (ADRD), and cognition. METHODS: The authors studied 2323 participants from the Memento study, a French nationwide clinical cohort. Social and lifestyle factors were education level, current household incomes, physical activity, leisure activities, and social network from which two continuous latent variables were computed: an early to midlife (EML) and a latelife (LL) indicator. Brain magnetic resonance imaging (MRI), lumbar puncture, and amyloid-positron emission tomography (PET) were used to define three latent variables: neurodegeneration, small vessel disease (SVD), and AD pathology. Cognitive function was defined as the underlying factor of a latent variable with four cognitive tests. Structural equation models were used to evaluate cross-sectional pathways between social and lifestyle factors and cognition. RESULTS: Participants' mean age was 70.9 years old, 62% were women, 28% were apolipoprotein-ε4 carriers, and 59% had a Clinical Dementia Rating (CDR) score of 0.5. Higher early to midlife social indicator was only directly associated with better cognitive function (direct β = 0.364 (0.322; 0.405), with no indirect pathway through ADRD biomarkers (total β = 0.392 (0.351; 0.429)). In addition to a direct effect on cognition (direct β = 0.076 (0.033; 0.118)), the association between latelife lifestyle indicator and cognition was also mostly mediated by an indirect effect through lower neurodegeneration (indirect β = 0.066 (0.042; 0.090) and direct β =  - 0.116 (- 0.153; - 0.079)), but not through AD pathology nor SVD. CONCLUSIONS: Early to midlife social factors are directly associated with higher cognitive functions. Latelife lifestyle factors may help preserve cognitive functions through lower neurodegeneration.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enSocial factors
dc.subject.enLifestyle factors
dc.subject.enCognitive function
dc.subject.enBrain markers
dc.subject.enPathology
dc.subject.enPathways
dc.title.enExplaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s13195-022-01013-8en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35585559en_US
bordeaux.journalAlzheimer's Research & Therapyen_US
bordeaux.page68en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamMEMENTOen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation Plan Alzheimeren_US
bordeaux.identifier.funderIDMinistère de l'Enseignement supérieur, de la Recherche et de l'Innovationen_US
bordeaux.identifier.funderIDCentre Hospitalier Universitaire de Bordeauxen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDMedical Research Councilen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.identifierhal-03701273
hal.version1
hal.date.transferred2022-06-21T20:26:41Z
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20Research%20&%20Therapy&rft.date=2022-05-18&rft.volume=14&rft.issue=1&rft.spage=68&rft.epage=68&rft.eissn=1758-9193%20(Electronic)&rft.issn=1758-9193%20(Electronic)&rft.au=GRASSET,%20Leslie&PROUST-LIMA,%20Cecile&MANGIN,%20Jean-Francois&HABERT,%20Marie-Odile&DUBOIS,%20Bruno&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
BPH_ART_2022_Grasset.pdf
Taille:
1.194Mo
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée