Factors associated with health-related quality of life in heart failure in 23,000 patients from 40 countries: Results of the G-CHF Research Program
| dc.rights.license | open | en_US |
| dc.contributor.author | JOHANSSON, Isabelle | |
| dc.contributor.author | BALASUBRAMANIAN, Kumar | |
| dc.contributor.author | BANGDIWALA, Shrikant | |
| dc.contributor.author | MIELNICZUK, Lisa | |
| dc.contributor.author | HAGE, Camilla | |
| dc.contributor.author | SHARMA, Sanjib Kumar | |
| dc.contributor.author | BRANCH, Kelly | |
| dc.contributor.author | ZHU, Jun | |
| dc.contributor.author | KRAGHOLM, Kristian | |
| dc.contributor.author | SLIWA, Karen | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ALLA, Francois | |
| dc.contributor.author | YONGA, Gerald | |
| dc.contributor.author | ROY, Ambuj | |
| dc.contributor.author | ORLANDINI, Andres | |
| dc.contributor.author | GRINVALDS, Alex | |
| dc.contributor.author | MCCREADY, Tara | |
| dc.contributor.author | POGOSOVA, Nana | |
| dc.contributor.author | STORK, Stefan | |
| dc.contributor.author | MCMURRAY, John J. V. | |
| dc.contributor.author | CONEN, David | |
| dc.contributor.author | YUSUF, Salim | |
| dc.date.accessioned | 2022-06-21T08:46:58Z | |
| dc.date.available | 2022-06-21T08:46:58Z | |
| dc.date.issued | 2022-05-15 | |
| dc.identifier.issn | 1879-0844 (Electronic) 1388-9842 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140288 | |
| dc.description.abstractEn | AIMS: To examine clinical and social correlates of health-related quality of life (HRQL), in patients with heart failure (HF) from high- (HIC), upper middle- (UMIC), lower middle-(LMIC) and low-income (LIC) countries. METHODS AND RESULTS: Between 2017 and 2020, we enrolled 23,292 patients with HF (32% inpatients, 61% men) from 40 countries in the Global Congestive Heart Failure Study. We recorded HRQL at baseline using Kansas City Cardiomyopathy Questionnaire (KCCQ)-12. In a cross-sectional analysis, we compared age- and sex-adjusted mean KCCQ-12 summary scores (SS: 0-100, higher=better) between patients from different country income levels. We used multivariable linear regression examining correlations (estimated coefficients) of KCCQ-12-SS with sociodemographic-, comorbidity-, treatment- and symptom-covariates. The adjusted model (37 covariates) was informed by univariable findings, clinical importance and backward selection. Mean age was 63 years and 40% were in NYHA class III-IV. Average HRQL was 55±0.5. It was 62.5 (95% CI 62.0-63.1) in HIC, 56.8 (56.1-57.4) in UMIC, 48.6 (48.0-49.3) in LMIC, and 38.5 (37.3-39.7) in LICs (p<0.0001). Strong correlates (estimated coefficient [95% CI]) of KCCQ-12-SS were NYHA class III vs class I/II (-12.1 [-12.8 to -11.4] and class IV vs. class I/II (-16.5 [-17.7 to -15.3]), effort dyspnea (-9.5[-10.2 to -8.8]) and living in LIC vs. HIC (-5.8[-7.1 to -4.4]). Symptoms explained most of the KCCQ-12-SS variability (partial R(2) =0.32 of total adjusted R(2) =0.51), followed by sociodemographic factors (R(2) =0.12). Results were consistent in populations across income levels. CONCLUSION: The most important correlates of HRQL in HF patients relate to HF symptom severity, irrespective of country-income level. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Health status | |
| dc.subject.en | Heart failure | |
| dc.subject.en | Correlates | |
| dc.subject.en | Global | |
| dc.subject.en | Quality of life | |
| dc.title.en | Factors associated with health-related quality of life in heart failure in 23,000 patients from 40 countries: Results of the G-CHF Research Program | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/ejhf.2535 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35570198 | en_US |
| bordeaux.journal | European Journal of Heart Failure | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | PHARES_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Bayer | en_US |
| hal.identifier | hal-03700430 | |
| hal.version | 1 | |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Heart%20Failure&rft.date=2022-05-15&rft.eissn=1879-0844%20(Electronic)%201388-9842%20(Linking)&rft.issn=1879-0844%20(Electronic)%201388-9842%20(Linking)&rft.au=JOHANSSON,%20Isabelle&BALASUBRAMANIAN,%20Kumar&BANGDIWALA,%20Shrikant&MIELNICZUK,%20Lisa&HAGE,%20Camilla&rft.genre=article |
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