Afficher la notice abrégée

High temporal resolution transcriptomic profiling delineates distinct patterns of interferon response following Covid-19 mRNA vaccination and SARS-CoV2 infection

dc.rights.licenseopenen_US
dc.contributor.authorRINCHAI, Darawan
dc.contributor.authorDEOLA, Sara
dc.contributor.authorZOPPOLI, Gabriele
dc.contributor.authorAHAMED KABEER, Basirudeen Syed
dc.contributor.authorTALEB, Sara
dc.contributor.authorPAVLOVSKI, Igor
dc.contributor.authorMAACHA, Selma
dc.contributor.authorGENTILCORE, Giusy
dc.contributor.authorTOUFIQ, Mohammed
dc.contributor.authorMATHEW, Lisa
dc.contributor.authorLIU, Li
dc.contributor.authorVEMPALLI, Fazulur Rehaman
dc.contributor.authorMUBARAK, Ghada
dc.contributor.authorLORENZ, Stephan
dc.contributor.authorSIVIERI, Irene
dc.contributor.authorCIRMENA, Gabriella
dc.contributor.authorDENTONE, Chiara
dc.contributor.authorCUCCAROLO, Paola
dc.contributor.authorGIACOBBE, Daniele
dc.contributor.authorBALDI, Federico
dc.contributor.authorGARBARINO, Alberto
dc.contributor.authorCIGOLINI, Benedetta
dc.contributor.authorCREMONESI, Paolo
dc.contributor.authorBEDOGNETTI, Michele
dc.contributor.authorBALLESTRERO, Alberto
dc.contributor.authorBASSETTI, Matteo
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHEJBLUM, Boris
ORCID: 0000-0003-0646-452X
IDREF: 189970316
dc.contributor.authorAUGUSTINE, Tracy
dc.contributor.authorPANHUYS, Nicholas Van
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorBRANCO, Ricardo
dc.contributor.authorCHEW, Tracey
dc.contributor.authorSHOJAEI, Maryam
dc.contributor.authorSHORT, Kirsty
dc.contributor.authorFENG, Carl
dc.contributor.authorZUGHAIER, Susu
dc.contributor.authorDE MARIA, Andrea
dc.contributor.authorTANG, Benjamin
dc.contributor.authorHSSAIN, Ali Ait
dc.contributor.authorBEDOGNETTI, Davide
dc.contributor.authorGRIVEL, Jean-Charles
dc.contributor.authorCHAUSSABEL, Damien
dc.date.accessioned2022-06-16T13:18:04Z
dc.date.available2022-06-16T13:18:04Z
dc.date.created2021
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140242
dc.description.abstractEnABSTRACT Knowledge of the factors contributing to the development of protective immunity after vaccination with COVID-19 mRNA vaccines is fragmentary. Thus we employed high- temporal-resolution transcriptome profiling and in-depth characterization of antibody production approaches to investigate responses to COVID-19 mRNA vaccination. There were marked differences in the timing and amplitude of the responses to the priming and booster doses. Notably, two distinct interferon signatures were identified, that differed based on their temporal patterns of induction. The first signature (S1), which was preferentially induced by type I interferon, peaked at day 2 post-prime and at day 1 post-boost, and in both instances was associated with subsequent development of the antibody response. In contrast, the second interferon signature (S2) peaked at day 1 both post-prime and post- boost but was found to be potently induced only post-boost, where it coincided with a robust inflammation peak. Notably, we also observed “post-prime-like” (S1 ++ ,S2 0/+ ) and “post-boost-like” (S1 ++ ,S2 ++ ) patterns of interferon response among COVID-19 patients. A post-boost-like signature was observed in most severely ill patients at admission to the intensive care unit and was associated with a shorter hospital stay. Interestingly, severely ill patients who stayed hospitalized the longest showed a peculiar pattern of interferon induction (S1 -/0 ,S2 + ), that we did not observe following the administration of mRNA vaccines. In summary, high temporal resolution profiling revealed an elaborate array of immune responses elicited by priming and booster doses of COVID-19 mRNA vaccines. Furthermore, it contributed to the identification of distinct interferon-response phenotypes underpinning vaccine immunogenicity and the course of COVID-19 disease.
dc.language.isoENen_US
dc.title.enHigh temporal resolution transcriptomic profiling delineates distinct patterns of interferon response following Covid-19 mRNA vaccination and SARS-CoV2 infection
dc.typeDocument de travail - Pré-publicationen_US
dc.identifier.doi10.1101/2021.12.12.472257en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamSISTM_BPHen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=RINCHAI,%20Darawan&DEOLA,%20Sara&ZOPPOLI,%20Gabriele&AHAMED%20KABEER,%20Basirudeen%20Syed&TALEB,%20Sara&rft.genre=preprint


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée