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Atherosclerotic Cardiovascular Events in Patients Infected With Human Immunodeficiency Virus and Hepatitis C Virus

dc.rights.licenseopenen_US
dc.contributor.authorTAN, Boun Kim
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHALOUNI, Mathieu
dc.contributor.authorCERON, Dominique Salmon
dc.contributor.authorCINAUD, Alexandre
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorESTERLE, Laure
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLOKO, Marc Arthur
dc.contributor.authorKATLAMA, Christine
dc.contributor.authorPOIZOT-MARTIN, Isabelle
dc.contributor.authorNEAU, Didier
dc.contributor.authorCHAS, Julie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMORLAT, Philippe
dc.contributor.authorROSENTHAL, Eric
dc.contributor.authorLACOMBE, Karine
dc.contributor.authorNAQVI, Alissa
dc.contributor.authorBARANGE, Karl
dc.contributor.authorBOUCHAUD, Olivier
dc.contributor.authorGERVAIS, Anne
dc.contributor.authorLASCOUX-COMBE, Caroline
dc.contributor.authorGARIPUY, Daniel
dc.contributor.authorALRIC, Laurent
dc.contributor.authorGOUJARD, Cecile
dc.contributor.authorMIAILHES, Patrick
dc.contributor.authorAUMAITRE, Hugues
dc.contributor.authorDUVIVIER, Claudine
dc.contributor.authorSIMON, Anne
dc.contributor.authorLOPEZ-ZARAGOZA, Jose-Luis
dc.contributor.authorZUCMAN, David
dc.contributor.authorRAFFI, François
dc.contributor.authorLAZARO, Estibaliz
dc.contributor.authorREY, David
dc.contributor.authorPIROTH, Lionel
dc.contributor.authorBOUE, François
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGILBERT, Camille
dc.contributor.authorBANI-SADR, Firouze
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDABIS, Francois
dc.contributor.authorSOGNI, Philippe
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.contributor.authorBOCCARA, Franck
dc.date.accessioned2022-06-16T13:02:53Z
dc.date.available2022-06-16T13:02:53Z
dc.date.issued2021-05-01
dc.identifier.issn1058-4838en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140241
dc.description.abstractEnBackground: An increased risk of cardiovascular disease (CVD) was reported in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV), without identifying factors associated with atherosclerotic CVD (ASCVD) events. Methods: HIV-HCV coinfected patients were enrolled in the Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS) CO13 HEPAVIH nationwide cohort. Primary outcome was total ASCVD events. Secondary outcomes were coronary and/or cerebral ASCVD events, and peripheral artery disease (PAD) ASCVD events. Incidences were estimated using the Aalen-Johansen method. Factors associated with ASCVD were identified using cause-specific Cox proportional hazards models. Results: At baseline, median age of the study population (N = 1213) was 45.4 (interquartile range [IQR] 42.1-49.0) years and 70.3% were men. After a median follow-up of 5.1 (IQR 3.9-7.0) years, the incidence was 6.98 (95% confidence interval [CI], 5.19-9.38) per 1000 person-years for total ASCVD events, 4.01 (2.78-6.00) for coronary and/or cerebral events, and 3.17 (2.05-4.92) for PAD ASCVD events. Aging (hazard ratio [HR] 1.06; 95% CI, 1.01-1.12), prior CVD (HR 8.48; 95% CI, 3.14-22.91), high total cholesterol (HR 1.43; 95% CI, 1.11-1.83), high-density lipoprotein cholesterol (HR 0.22; 95% CI, 0.08-0.63), statin use (HR 3.31; 95% CI, 1.31-8.38), and high alcohol intake (HR 3.18; 95% CI, 1.35-7.52) were independently associated with total ASCVD events, whereas undetectable baseline viral load (HR 0.41, 95% CI, 0.18-0.96) was associated with coronary and/or cerebral events. Conclusions: HIV-HCV coinfected patients experienced a high incidence of ASCVD events. Some traditional cardiovascular risk factors were the main determinants of ASCVD. Controlling cholesterol abnormalities and maintaining undetectable HIV RNA are essential to control cardiovascular risk.
dc.language.isoENen_US
dc.subject.enatherosclerosis
dc.subject.encardiovascular
dc.subject.encoinfection
dc.subject.enhepatitis C virus
dc.subject.enHIV
dc.title.enAtherosclerotic Cardiovascular Events in Patients Infected With Human Immunodeficiency Virus and Hepatitis C Virus
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cid/ciaa1014en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalClinical infectious diseasesen_US
bordeaux.pagee215 - e223en_US
bordeaux.volume72en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20infectious%20diseases&rft.date=2021-05-01&rft.volume=72&rft.issue=9&rft.spage=e215%20-%20e223&rft.epage=e215%20-%20e223&rft.eissn=1058-4838&rft.issn=1058-4838&rft.au=TAN,%20Boun%20Kim&CHALOUNI,%20Mathieu&CERON,%20Dominique%20Salmon&CINAUD,%20Alexandre&ESTERLE,%20Laure&rft.genre=article


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