Afficher la notice abrégée

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUCH, Isabelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorEDJOLO, Arlette
dc.contributor.authorLAURENT, Bernard
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
dc.date.accessioned2022-06-15T08:32:37Z
dc.date.available2022-06-15T08:32:37Z
dc.date.issued2022-05
dc.identifier.issn1099-1166 (Electronic) 0885-6230 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140225
dc.description.abstractEnINTRODUCTION: Chronic pain (CP) was associated with cognitive impairment in previous studies. However, the longitudinal association between CP and dementia remains under debate. We aimed to assess the prospective link between CP and long-term dementia risk in a population-based cohort of older participants, considering covariables linked to CP and cognitive functioning. METHODS: The study sample was selected from the PAQUID study, an ongoing cohort of older community-dwellers aged 65 years and over at baseline; Information regarding CP and analgesics consumption was collected using questionnaires. Dementia was clinically assessed every 2 years. The population was divided into 4 groups according to CP and analgesic drugs intake (CP+/A+, CP+/A-, CP-/A+, CP-/A-). An illness-death model was used to estimate the link between CP and incident dementia risk controlled for sex, educational level, comorbidities, depression, antidepressant drugs and analgesics. RESULTS: Five hundred ninety three participants (364 women) who completed a CP questionnaire, were included. They were followed-up over 24 years (mean follow-up: 11.3 years, SD 7.3). A total of 223 participants (32.5%) had CP, among them 88 (38.6%) took analgesic drugs. Compared to CP-/A- group, CP+/A+ participants had a higher risk of developing dementia in the univariate model (hazard ratio (HR) = 1.73, 95%CI:1.18-2.56; p = 0.0051). However, these results did not persist in the multivariate models (aHR = 1.23, 95%CI:0.88-1.73; p = 0.23). No significant risk for dementia were observed in CP-/A+ and CP+/A- (HR = 1.30, 95%CI:0.84-2.01; p = 0.23 and HR = 1.36, 95%CI:0.95-1.96; p = 0.09, respectively). CONCLUSION: Our results failed to show a significant relationship between the presence of CP and long-term dementia risk, suggesting that the cognitive decline associated with CP observed in the literature does not appear to be related to Alzheimer's disease or related disorders.
dc.language.isoENen_US
dc.subject.enChronic pain
dc.subject.enCohort
dc.subject.enDementia
dc.subject.enOlder adults
dc.title.enChronic pain and long-term dementia risk in older adults: Results from a 24-year longitudinal study
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/gps.5713en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35434855en_US
bordeaux.journalInternational Journal of Geriatric Psychiatryen_US
bordeaux.volume37en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNovartisen_US
bordeaux.identifier.funderIDIpsenen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
hal.identifierhal-03696355
hal.version1
hal.date.transferred2022-06-15T22:22:11Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Geriatric%20Psychiatry&rft.date=2022-05&rft.volume=37&rft.issue=5&rft.eissn=1099-1166%20(Electronic)%200885-6230%20(Linking)&rft.issn=1099-1166%20(Electronic)%200885-6230%20(Linking)&rft.au=ROUCH,%20Isabelle&EDJOLO,%20Arlette&LAURENT,%20Bernard&DARTIGUES,%20Jean-Francois&AMIEVA,%20Helene&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée