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Sex-specific Genome Wide Association Study Of Early-onset Ischemic Stroke

dc.rights.licenseopenen_US
dc.contributor.authorTOMPPO, Liisa
dc.contributor.authorRANNIKMAE, Kristiina
dc.contributor.authorSTANNE, Tara M.
dc.contributor.authorPUTAALA, Jukka
dc.contributor.authorSTRBIAN, Daniel
dc.contributor.authorJERN, Christina
dc.contributor.authorDE LEEUW, Frank Erik
dc.contributor.authorCADENAS, Israel Fernandez
dc.contributor.authorSLOWIK, Agnieszka M.
dc.contributor.authorBONCORAGLIO, Giorgio
dc.contributor.authorLINDGREN, Arne
dc.contributor.authorCONDE, Jordi J.
dc.contributor.authorSCHMIDT, Reinhold
dc.contributor.authorSHARMA, Pankaj
dc.contributor.authorLEMMENS, Robin
dc.contributor.authorMELANDER, Olle
dc.contributor.authorROTHWELL, Peter
dc.contributor.authorLEVI, Christopher
dc.contributor.authorSUDLOW, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorMETSO, Tiina
dc.contributor.authorPARE, Guillaume
dc.contributor.authorMARKUS, Hugh
dc.contributor.authorSALEHEEN, Danish
dc.contributor.authorDANESH, John
dc.contributor.authorZAND, Ramin
dc.contributor.authorWORRALL, Bradford B.
dc.contributor.authorMESCHIA, James F.
dc.contributor.authorRUNDEK, Tatjana
dc.contributor.authorWOO, Daniel
dc.contributor.authorLEE, Jin Moo
dc.contributor.authorIRVIN, Marguerite R.
dc.contributor.authorMCDONOUGH, Caitrin W.
dc.contributor.authorREXRODE, Kathryn M.
dc.contributor.authorWASSERTHEIL-SMOLLER, Sylvia W.
dc.contributor.authorROSAND, Jonathan
dc.contributor.authorGIEGER, Christian
dc.contributor.authorMULLER-NURASYID, Martina
dc.contributor.authorSALOMAA, Veikko V.
dc.contributor.authorKAMATANI, Yoichiro
dc.contributor.authorWALTERS, Robin
dc.contributor.authorCHEN, Zhengming
dc.contributor.authorDICHGANS, Martin
dc.contributor.authorMALIK, Rainer
dc.contributor.authorGAYNOR, Brady
dc.contributor.authorCOLE, John
dc.contributor.authorXU, Huichun
dc.contributor.authorMITCHELL, Braxton D.
dc.contributor.authorKITTNER, Steven J.
dc.contributor.authorEARLY-ONSET STROKE, Consortium
dc.date.accessioned2022-06-15T07:48:36Z
dc.date.available2022-06-15T07:48:36Z
dc.date.issued2022-02
dc.identifier.issn0039-2499en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140220
dc.description.abstractEnIntroduction: Genetic studies of early-onset disease have been an effective strategy to identify novel pathways and drug targets generalizable also to later-onset disease. Few studies have investigated the sex-specific genetic associations with early-onset ischemic stroke even though several features of ischemic stroke differ between males and females. We hypothesized that stratifying the GWAS by sex would reveal novel stroke loci. Methods: We performed a transethnic ischemic stroke GWAS of 3,056 female cases and 4,462 male cases < 60 years-old and 16,192 and 16,048 sex-matched controls, respectively, from the Early Onset Stroke Genetics Consortium. Results: We identified a significant association in women with a locus in close proximity to TMX1, a transmembrane platelet protein that inhibits platelet function. Additionally, we identified 2 other suggestive (P < 5 x 10-6) loci in females (see Table), i.e., at APOH, which encodes beta2-glycoprotein I, an established GWAS locus for lipoprotein(a), and LRFN2 which has been previously reported to associate with obesity-related measures and type II diabetes. We observed suggestive evidence for association in males with MMP3/MMP12, a known stroke susceptibility locus. Conclusions: Despite a very modest sample size, sex-specific analyses identified suggestive associations at biologically important novel loci in females and a known stroke locus in males. Further studies of sex-specific associations in both early- and later-onset ischemic stroke are needed.
dc.language.isoENen_US
dc.subject.enGender differences
dc.subject.enIschemic stroke
dc.subject.enGenome-wide association studies (GWAS)
dc.title.enSex-specific Genome Wide Association Study Of Early-onset Ischemic Stroke
dc.typeArticle de revueen_US
dc.identifier.doi10.1161/str.53.suppl_1.154en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalStrokeen_US
bordeaux.volume53en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issueSuppl_1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03696351
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Stroke&amp;rft.date=2022-02&amp;rft.volume=53&amp;rft.issue=Suppl_1&amp;rft.eissn=0039-2499&amp;rft.issn=0039-2499&amp;rft.au=TOMPPO,%20Liisa&amp;RANNIKMAE,%20Kristiina&amp;STANNE,%20Tara%20M.&amp;PUTAALA,%20Jukka&amp;STRBIAN,%20Daniel&amp;rft.genre=article


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