GINESTE, Stéphane; LONETTI, Barbara; YON, Marjorie; GIERMANSKA, Joanna; DI COLA, Emanuela; SZTUCKI, Michael; COPPEL, Yannick; MINGOTAUD, Anne-FranÃ§oise; CHAPEL, Jean-Paul; MARTY, Jean-Daniel; MINGOTAUD, Christophe

doi:10.1016/j.jcis.2021.11.077

Langue

Article de revue

Ce document a été publié dans

Journal of Colloid and Interface Science. 2022, vol. 609, p. 698-706

Résumé en anglais

The addition of gallium ions to a solution of a double-hydrophilic block copolymer, i.e. poly(ethylene oxide)-block-poly(acrylic acid), leads to the spontaneous formation of highly monodisperse micelles with a Hybrid PolyIon Complexes (HPICs) core. By combining several techniques, a precise description of the HPIC architecture was achieved. In particular and for the first time, NMR and anomalous small angle X-ray scattering (ASAXS) enable tracking of the inorganic ions in solution and highlighting the co-localization of the gallium and the poly(acrylic acid) blocks in a rigid structure at the core of the micelle. Such a core has a radius of ca 4.3 nm while the complete nano-object with its poly(ethylene oxide) shell has a total radius of ca 11 nm. The aggregation number was also estimated using the ASAXS results. This comprehensive structural characterization of the Ga HPICs corroborates the assumptions made for HPICs based on other inorganic ions and demonstrates the universality of the HPIC structure leading, for example, to new families of contrast agents in medical imaging.< Réduire

Mots clés

Polyion

ASAXS

Micelle

Polyme

r Gallium

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140170

DOI

http://dx.doi.org/10.1016/j.jcis.2021.11.077

Project ANR

Complexes hybrides polyioniques pour l'imagerie médicale - ANR-19-CE09-0011

Unités de recherche

Centre de Recherche Paul Pascal (CRPP) - UMR 5031

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Hybrid polymeric micelles stabilized by gallium ions: Structural investigation