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Stroke Genetics: Discovery, Insight Into Mechanisms, and Clinical Perspectives
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DEBETTE, Stephanie | |
| dc.contributor.author | MARKUS, Hugh S. | |
| dc.date.accessioned | 2022-05-16T12:17:57Z | |
| dc.date.available | 2022-05-16T12:17:57Z | |
| dc.date.issued | 2022-04-15 | |
| dc.identifier.issn | 1524-4571 (Electronic) 0009-7330 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140069 | |
| dc.description.abstractEn | Stroke is the second leading cause of death worldwide and a complex, heterogeneous condition. In this review, we provide an overview of the current knowledge on monogenic and multifactorial forms of stroke, highlighting recent insight into the continuum between these. We describe how, in recent years, large-scale genome-wide association studies have enabled major progress in deciphering the genetic basis for stroke and its subtypes, although more research is needed to interpret these findings. We cover the potential of stroke genetics to reveal novel pathophysiological processes underlying stroke, to accelerate the discovery of new therapeutic approaches, and to identify individuals in the population who are at high risk of stroke and could be targeted for tailored preventative interventions. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Stroke | |
| dc.subject.en | Genomics | |
| dc.subject.en | Cause of death | |
| dc.subject.en | Small vessel disease | |
| dc.subject.en | Genome-wide association studies | |
| dc.subject.en | White matter | |
| dc.subject.en | Gray matter | |
| dc.title.en | Stroke Genetics: Discovery, Insight Into Mechanisms, and Clinical Perspectives | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1161/circresaha.122.319950 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35420914 | en_US |
| bordeaux.journal | Circulation Research | en_US |
| bordeaux.page | 1095-1111 | en_US |
| bordeaux.volume | 130 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 8 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | ELEANOR_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03669185 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-05-16T12:17:58Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Circulation%20Research&rft.date=2022-04-15&rft.volume=130&rft.issue=8&rft.spage=1095-1111&rft.epage=1095-1111&rft.eissn=1524-4571%20(Electronic)%200009-7330%20(Linking)&rft.issn=1524-4571%20(Electronic)%200009-7330%20(Linking)&rft.au=DEBETTE,%20Stephanie&MARKUS,%20Hugh%20S.&rft.genre=article |
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