Show simple item record

Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels

dc.rights.licenseopenen_US
dc.contributor.authorSARNOWSKI, Chloe
dc.contributor.authorGHANBARI, Mohsen
dc.contributor.authorBIS, Joshua C.
dc.contributor.authorLOGUE, Mark
dc.contributor.authorFORNAGE, Myriam
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMISHRA, Aniket
dc.contributor.authorAHMAD, Shahzad
dc.contributor.authorBEISER, Alexa S.
dc.contributor.authorBOERWINKLE, Eric
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUTELOUP, Vincent
dc.contributor.authorCHOURAKI, Vincent
dc.contributor.authorCUPPLES, L. Adrienne
dc.contributor.authorDAMOTTE, Vincent
dc.contributor.authorDECARLI, Charles S.
dc.contributor.authorDESTEFANO, Anita L.
dc.contributor.authorDJOUSSE, Luc
dc.contributor.authorFOHNER, Alison E.
dc.contributor.authorFRANZ, Carol E.
dc.contributor.authorKAUTZ, Tiffany F.
dc.contributor.authorLAMBERT, Jean-Charles
dc.contributor.authorLYONS, Michael J.
dc.contributor.authorMOSLEY, Thomas H.
dc.contributor.authorMUKAMAL, Kenneth J.
dc.contributor.authorPASE, Matthew P.
dc.contributor.authorPORTILLA FERNANDEZ, Eliana C.
dc.contributor.authorRISSMAN, Robert A.
dc.contributor.authorSATIZABAL, Claudia L.
dc.contributor.authorVASAN, Ramachandran S.
dc.contributor.authorYAQUB, Amber
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorLAUNER, Lenore J.
dc.contributor.authorKREMEN, William S.
dc.contributor.authorLONGSTRETH, William T.
dc.contributor.authorIKRAM, M. Arfan
dc.contributor.authorSESHADRI, Sudha
dc.date.accessioned2022-05-11T09:01:30Z
dc.date.available2022-05-11T09:01:30Z
dc.date.issued2022-04-08
dc.identifier.issn2399-3642en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140035
dc.description.abstractEnCirculating total-tau levels can be used as an endophenotype to identify genetic risk factors for tauopathies and related neurological disorders. Here, we confirmed and better characterized the association of the 17q21 MAPT locus with circulating total-tau in 14,721 European participants and identified three novel loci in 953 African American participants (4q31, 5p13, and 6q25) at P < 5 × 10(-8). We additionally detected 14 novel loci at P < 5 × 10(-7), specific to either Europeans or African Americans. Using whole-exome sequence data in 2,279 European participants, we identified ten genes associated with circulating total-tau when aggregating rare variants. Our genetic study sheds light on genes reported to be associated with neurological diseases including stroke, Alzheimer's, and Parkinson's (F5, MAP1B, and BCAS3), with Alzheimer's pathological hallmarks (ADAMTS12, IL15, and FHIT), or with an important function in the brain (PARD3, ELFN2, UBASH3B, SLIT3, and NSD3), and suggests that the genetic architecture of circulating total-tau may differ according to ancestry.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enMeta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s42003-022-03287-yen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35396452en_US
bordeaux.journalCommunications Biologyen_US
bordeaux.volume5en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03664665
hal.version1
hal.date.transferred2022-05-11T09:01:35Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Communications%20Biology&amp;rft.date=2022-04-08&amp;rft.volume=5&amp;rft.issue=1&amp;rft.eissn=2399-3642&amp;rft.issn=2399-3642&amp;rft.au=SARNOWSKI,%20Chloe&amp;GHANBARI,%20Mohsen&amp;BIS,%20Joshua%20C.&amp;LOGUE,%20Mark&amp;FORNAGE,%20Myriam&amp;rft.genre=article


Files in this item

Thumbnail
Name:
BPH_CB_2022_Sarnowski.pdf
Size:
1.348Mb
Format:
PDF
View/Open
Thumbnail
Name:
license_rdf
Size:
914bytes
Format:
application/rdf+xml
View/Open

This item appears in the following Collection(s)

Show simple item record