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Characterization of a Unique γδ T-Cell Subset as a Specific Marker of Cytomegalovirus Infection Severity

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorKAMINSKI, Hannah
dc.contributor.authorMENARD, C.
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorEL HAYANI, Bouchra
dc.contributor.authorADJIBABI, A.-N.
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorMARSERES, Gabriel
dc.contributor.authorCOURANT, M.
dc.contributor.authorZOUINE, A.
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorPITARD, Vincent
dc.contributor.authorGARRIGUE, I.
dc.contributor.authorBURREL, S.
hal.structure.identifierHétérochimie moléculaire et macromoléculaire [HMM]
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
hal.structure.identifierPathologies infectieuses et cancers : aspects biologiques et thérapeutiques [PICABT]
hal.structure.identifierService de virologie et d'immunologie biologique
hal.structure.identifierBiogéosciences [UMR 6282] [BGS]
hal.structure.identifierService d'immunologie et d'immunogénétique [Bordeaux]
hal.structure.identifierCHU Bordeaux
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorMOREAU, Jean-Francois
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorCOUZI, Lionel
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorVISENTIN, Jonathan
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorMERVILLE, Pierre
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorDECHANET-MERVILLE, Julie
dc.date.accessioned2022-05-10T12:48:54Z
dc.date.available2022-05-10T12:48:54Z
dc.date.issued2021-02
dc.identifier.issn1537-6613 (online) 0022-1899 (print)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140021
dc.description.abstractEnCytomegalovirus (CMV) is a major infectious cause of death and disease after transplantation. We have previously demonstrated that the tissue-associated adaptive Vδ2neg γδ T cells are key effectors responding to CMV and associated with recovery, contrasting with their innatelike circulating counterparts, the Vγ9posVδ2pos T cells that respond to phosphoantigens but not to CMV. A third Vγ9negVδ2pos subgroup with adaptive functions has been described in adults. In the current study, we demonstrate that these Vγ9negVδ2pos T cells are also components of the CMV immune response while presenting with distinct characteristics from Vδ2neg γδ T cells. In a cohort of kidney transplant recipients, CMV seropositivity was the unique clinical parameter associated with Vγ9negVδ2pos T-cell expansion and differentiation. Extensive phenotyping demonstrated their substantial cytotoxic potential and activation during acute CMV primary infection or reinfection. In vitro, Vγ9negVδ2pos T cells responded specifically to CMV-infected cells in a T-cell receptor–dependent manner and through strong interferon γ production. Finally, Vγ9negVδ2pos T cells were the only γδ T-cell subset in which expansion was tightly correlated with the severity of CMV disease. To conclude, our results identify a new player in the immune response against CMV and open interesting clinical perspectives for using Vγ9negVδ2pos T cells as an immune marker for CMV disease severity in immunocompromised patients.
dc.language.isoENen_US
dc.subject.enCMV infection
dc.subject.enGamma-delta T cells
dc.subject.enKidney transplant recipients
dc.title.enCharacterization of a Unique γδ T-Cell Subset as a Specific Marker of Cytomegalovirus Infection Severity
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/infdis/jiaa400en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed32622351en_US
bordeaux.journalJournal of Infectious Diseasesen_US
bordeaux.page655-666en_US
bordeaux.volume223en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation du Reinen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDLigue Contre le Canceren_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Infectious%20Diseases&rft.date=2021-02&rft.volume=223&rft.issue=4&rft.spage=655-666&rft.epage=655-666&rft.eissn=1537-6613%20(online)%200022-1899%20(print)&rft.issn=1537-6613%20(online)%200022-1899%20(print)&rft.au=KAMINSKI,%20Hannah&MENARD,%20C.&EL%20HAYANI,%20Bouchra&ADJIBABI,%20A.-N.&MARSERES,%20Gabriel&rft.genre=article


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