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Update on the cellular pathogenesis of lupus

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorGENSOUS, Noemie
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorBOIZARD-MORACCHINI, Andrea
dc.contributor.authorLAZARO, Estibaliz
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorRICHEZ, Christophe
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorBLANCO, Patrick
dc.date.accessioned2022-05-09T10:04:40Z
dc.date.available2022-05-09T10:04:40Z
dc.date.issued2021-03
dc.identifier.issn1531-6963 (online) 1040-8711 (print)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140002
dc.description.abstractEnPurpose of review Aberrations in the innate and in the adaptive arms of the immune system play both important roles in the initiation and progression of systemic lupus erythematosus (SLE). The aim of this study was to provide an update on the most recent findings on the cellular pathogenesis of SLE. Our overview focused particularly on results obtained over the last 18 months. Recent findings Recent observations have provided an improved understanding of the importance of low-density granulocytes, a highly proinflammatory subset of neutrophils. We also highlighted in this work recent descriptions of the various cellular sources associated with the interferon signature. In addition, novel contributions have also developed our understanding of the potential importance of extrafollicular T-B-cell interactions in SLE pathogenesis. Finally, the role of recently described B and T-cell subsets, that is, atypical memory B cells, T-peripheral helper cells, and Th10 T cells, were also reviewed. Summary Recent findings in the cellular pathogenesis of SLE give a deeper comprehension of previously described mechanisms which drive SLE pathogenesis and shed light on novel players in immune dysregulation that could help to identify potential therapeutic targets.
dc.language.isoENen_US
dc.subject.enAutoimmunity
dc.subject.enB cells
dc.subject.enSystemic lupus erythematosus
dc.subject.enT cells
dc.subject.enType I interferon
dc.title.enUpdate on the cellular pathogenesis of lupus
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/BOR.0000000000000775en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed33394603en_US
bordeaux.journalCurrent Opinion in Rheumatologyen_US
bordeaux.page190-196en_US
bordeaux.volume33en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03662379
hal.version1
hal.date.transferred2022-05-09T10:04:42Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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