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Use of a novel peptide welding technology platform for the development of B- and T-cell epitope-based vaccines
| dc.rights.license | open | en_US |
| dc.contributor.author | NICOLI, F. | |
| dc.contributor.author | PACIFICO, S. | |
| dc.contributor.author | GALLERANI, E. | |
| dc.contributor.author | MARZOLA, E. | |
| dc.contributor.author | ALBANESE, V. | |
| dc.contributor.author | FINESSI, V. | |
| dc.contributor.author | LLEWELLYN-LACEY, S. | |
| dc.contributor.author | PRICE, D.A. | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | APPAY, Victor | |
| dc.contributor.author | MARCONI, P. | |
| dc.contributor.author | GUERRINI, R. | |
| dc.contributor.author | CAPUTO, A. | |
| dc.contributor.author | GAVIOLI, R. | |
| dc.date.accessioned | 2022-05-04T07:51:46Z | |
| dc.date.available | 2022-05-04T07:51:46Z | |
| dc.date.issued | 2021-05-19 | |
| dc.identifier.issn | 2076-393X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139976 | |
| dc.description.abstractEn | Peptide vaccines incorporating B- and T-cell epitopes have shown promise in the context of various cancers and infections. These vaccines are relatively simple to manufacture, but more immunogenic formulations are considered a priority. We developed tetrabranched derivatives for this purpose based on a novel peptide welding technology (PWT). PWTs provide molecular scaffolds for the efficient synthesis of ultrapure peptide dendrimers, which allow the delivery of multiple ligands within a single macromolecular structure. Peptide vaccines incorporating T-cell epitopes derived from melanoma and B-cell epitopes derived from human immunodeficiency virus, synthesized using this approach, elicited primary immune responses in vitro and in vivo. Subcutaneous administration of the B-cell epitope-based vaccines also elicited more potent humoral responses than subcutaneous administration of the corresponding peptides alone. Highly immunogenic peptide epitope-based vaccines can therefore be generated quickly and easily using a novel PWT. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Adaptive immune responses | |
| dc.subject.en | B-cell epitopes | |
| dc.subject.en | Peptide vaccines | |
| dc.subject.en | T-cell epitopes | |
| dc.title.en | Use of a novel peptide welding technology platform for the development of B- and T-cell epitope-based vaccines | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/vaccines9050526 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 34069535 | en_US |
| bordeaux.journal | Vaccines | en_US |
| bordeaux.volume | 9 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Wellcome Trust | en_US |
| bordeaux.identifier.funderID | Università degli Studi di Ferrara | en_US |
| hal.identifier | hal-03658518 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-05-04T07:51:49Z | |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Vaccines&rft.date=2021-05-19&rft.volume=9&rft.issue=5&rft.eissn=2076-393X&rft.issn=2076-393X&rft.au=NICOLI,%20F.&PACIFICO,%20S.&GALLERANI,%20E.&MARZOLA,%20E.&ALBANESE,%20V.&rft.genre=article |
