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Efficacy of plasmapheresis and semi-selective immunoadsorption for removal of anti-HLA antibodies

dc.rights.licenseopenen_US
dc.contributor.authorJAMBON, Frederic
dc.contributor.authorMERVILLE, Pierre
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorGUIDICELLI, G.
dc.contributor.authorTATON, B.
dc.contributor.authorDE PRECIGOUT, V.
dc.contributor.authorCOUZI, Lionel
dc.contributor.authorMOREAU, K.
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorVISENTIN, Jonathan
dc.date.accessioned2022-05-03T13:53:55Z
dc.date.available2022-05-03T13:53:55Z
dc.date.issued2021-06
dc.identifier.issn1098-1101 (online) 0733-2459 (print)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/139973
dc.description.abstractEnBackground: In organ transplantation, apheresis is frequently used for removal of anti-HLA antibodies. However, it is unclear whether plasmapheresis (PP) or semi-selective immunoadsorption (IA) should be employed, and the optimal number of apheresis sessions required to reach post-treatment objectives is also unknown. Methods: We enrolled 43 patients from Bordeaux University Hospital who were treated with PP (n=29) or IA (n=14) for antibody-mediated rejection or pre-transplant desensitization. Using Luminex single-antigen flow beads, we assessed the initial mean fluorescence intensity (MFI) of 1416 positive beads with MFIs obtained after 7 to 8 apheresis sessions (extended protocol) and, if a serum was available, after the first four sessions (short protocol). Results: MFI reduction after extended apheresis protocol was stronger with IA [87% (61%-100%)] than with PP [73% (22%-100%)] (P <.001). Indeed, 59% of the beads had a final MFI < 2000 with IA, whereas only 38% with PP (P <.001). The efficacy of removal depended on initial MFI but not on HLA specificity. A short protocol of apheresis showed excellent results without superiority of IA over PP for antibodies with an initial MFI < 3000. For antibodies showing MFI ?2000 after four sessions, the residual MFI predicted the effectiveness of four additional sessions. Conclusion: Monitoring the MFI of anti-HLA antibodies before and during apheresis protocol can guide physicians in the selection of apheresis technique and the number of sessions to be performed.
dc.language.isoENen_US
dc.subject.enAnti-HLA antibodies
dc.subject.enImmunoadsorption
dc.subject.enOrgan transplantation
dc.subject.enPlasmapheresis
dc.title.enEfficacy of plasmapheresis and semi-selective immunoadsorption for removal of anti-HLA antibodies
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/jca.21858en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed33253430en_US
bordeaux.journalJournal of Clinical Apheresisen_US
bordeaux.page291-298en_US
bordeaux.volume36en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03658146
hal.version1
hal.date.transferred2022-05-03T13:53:56Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Clinical%20Apheresis&amp;rft.date=2021-06&amp;rft.volume=36&amp;rft.issue=3&amp;rft.spage=291-298&amp;rft.epage=291-298&amp;rft.eissn=1098-1101%20(online)%200733-2459%20(print)&amp;rft.issn=1098-1101%20(online)%200733-2459%20(print)&amp;rft.au=JAMBON,%20Frederic&amp;MERVILLE,%20Pierre&amp;GUIDICELLI,%20G.&amp;TATON,%20B.&amp;DE%20PRECIGOUT,%20V.&amp;rft.genre=article


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