Diagnostic accuracy and clinical impact of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in Positron Emission Tomography - Computed Tomography (PET-CT)-positive mediastinal lymphadenopathies in subjects with thoracic or extra-thoracic malignancy
| dc.rights.license | open | en_US |
| dc.contributor.author | BECHADE, Dominique | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BELLERA, Carine | |
| dc.contributor.author | GAUQUELIN, Lisa | |
| dc.contributor.author | SOUBEYRAN, Isabelle | |
| dc.contributor.author | MCKELVIE-SEBILEAU, Pippa | |
| dc.contributor.author | DEBLED, Marc | |
| dc.contributor.author | CHOMY, Francois | |
| dc.contributor.author | ROUBAUD, Guilhem | |
| dc.contributor.author | FONCK, Marianne | |
| dc.contributor.author | PERNOT, Simon | |
| dc.contributor.author | ROCH, Alexandre | |
| dc.contributor.author | CAZEAU, Anne-Laure | |
| dc.date.accessioned | 2022-04-25T12:18:58Z | |
| dc.date.available | 2022-04-25T12:18:58Z | |
| dc.date.issued | 2022-03-24 | |
| dc.identifier.issn | 2210-741X (Electronic) 2210-7401 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139922 | |
| dc.description.abstractEn | BACKGROUND: The high sensitivity of PET-CT can identify hypermetabolic mediastinal adenopathies during cancer management, but specificity is low and a biopsy is sometimes required to eliminate benign adenopathies. METHODS: This prospective diagnostic accuracy study included patients with hypermetabolic mediastinal lymphadenopathies revealed on PET-CT, during either the initial management of a cancer, treatment evaluation, or monitoring. All patients underwent EUS-FNA. Diagnose of malignancy based on cytological analysis following EUS-FNA were compared with clinical and radiological follow-up informations. Treatment strategy decided before the results of the EUS-FNA pathology reports (Multidisciplinary Team Meeting [MTM-1]) was recorded and compared to the treatment strategy decided once pathological data from EUS-FNA were available (MTM-2). MAIN FINDINGS: Between 2013 and 2018, 75 patients were included with 47 eligible and evaluable patients. The sensitivity, specificity, and positive and negative predictive values of EUS-FNA were 93%, 100%, 100% and 90%, respectively. The concordance value between the therapeutic strategies determined for MTM-1 and MTM-2 was 44.7%. There were no significant differences in the intensity of fixation on PET-CT between malignant and benign lesions. CONCLUSION: The diagnostic accuracy of the minimally invasive EUS-FNA procedure is sufficiently robust to avoid surgical diagnosis. The combination of PET-CT and EUS-FNA may alter the therapeutic strategy that would be considered after PET-CT alone. REGISTRATION: NCT01892501. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Endoscopic ultrasound-guided fine-needle aspiration | |
| dc.subject.en | Mediastinal lymphadenopathy | |
| dc.subject.en | Positron Emission Tomography - Computed Tomography | |
| dc.subject.en | Clinical impact on cancer management | |
| dc.title.en | Diagnostic accuracy and clinical impact of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in Positron Emission Tomography - Computed Tomography (PET-CT)-positive mediastinal lymphadenopathies in subjects with thoracic or extra-thoracic malignancy | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.clinre.2022.101912 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35341993 | en_US |
| bordeaux.journal | Clinics and Research in Hepatology and Gastroenterology | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | EPICENE_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Ligue Contre le Cancer | en_US |
| bordeaux.identifier.funderID | Institut Bergonié | en_US |
| hal.identifier | hal-03651026 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-04-25T12:19:00Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinics%20and%20Research%20in%20Hepatology%20and%20Gastroenterology&rft.date=2022-03-24&rft.eissn=2210-741X%20(Electronic)%202210-7401%20(Linking)&rft.issn=2210-741X%20(Electronic)%202210-7401%20(Linking)&rft.au=BECHADE,%20Dominique&BELLERA,%20Carine&GAUQUELIN,%20Lisa&SOUBEYRAN,%20Isabelle&MCKELVIE-SEBILEAU,%20Pippa&rft.genre=article |
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