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dc.rights.licenseopenen_US
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorGUY, Alexandre
dc.contributor.authorPOISSON, Johanne
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorJAMES, Chloe
dc.date.accessioned2022-04-22T07:36:10Z
dc.date.available2022-04-22T07:36:10Z
dc.date.issued2021-01-01
dc.identifier.issn1476-5551en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/139899
dc.description.abstractEnThrombosis, both in arterial and venous territories, is the major complication of myeloproliferative neoplasms and is responsible for a high rate of morbidity and mortality. The currently accepted risk factors are an age over 60 years and a history of thrombosis. However, many complex mechanisms contribute to this increased prothrombotic risk, with involvement of all blood cell types, plasmatic factors, and endothelial cells. Besides, some cardiovascular events may originate from arterial vasospasm that could contribute to thrombotic complications. In this review, we discuss recent results obtained in mouse models in the light of data obtained from clinical studies. We emphasize on actors of thrombosis that are currently not targeted with current therapeutics but could be promising targets, i.e, neutrophil extracellular traps and vascular reactivity.
dc.language.isoENen_US
dc.subject.enAnimals
dc.subject.enBiomarkers
dc.subject.enBlood Cells
dc.subject.enBlood Coagulation
dc.subject.enBlood Coagulation Factors
dc.subject.enBlood Vessels
dc.subject.enCardiovascular Diseases
dc.subject.enDisease Management
dc.subject.enDisease Models
dc.subject.enAnimal
dc.subject.enDisease Susceptibility
dc.subject.enFusion Proteins
dc.subject.enbcr-abl
dc.subject.enHemostasis
dc.subject.enHumans
dc.subject.enMutation
dc.subject.enMyeloproliferative Disorders
dc.subject.enRisk Assessment
dc.subject.enRisk Factors
dc.subject.enSignal Transduction
dc.subject.enThrombosis
dc.title.enPathogenesis of cardiovascular events in BCR-ABL1-negative myeloproliferative neoplasms.
dc.title.alternativeLeukemiaen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41375-021-01170-zen_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.identifier.pubmed33658660en_US
bordeaux.journalLeukemiaen_US
bordeaux.page935-955en_US
bordeaux.volume35en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Leukemia&rft.date=2021-01-01&rft.volume=35&rft.issue=4&rft.spage=935-955&rft.epage=935-955&rft.eissn=1476-5551&rft.issn=1476-5551&rft.au=GUY,%20Alexandre&POISSON,%20Johanne&JAMES,%20Chloe&rft.genre=article


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