Post-vaccination SARS-cov-2 infection in nursing home residents, Bordeaux, France
| dc.rights.license | open | en_US |
| dc.contributor.author | LARTIGAU, Marion | |
| dc.contributor.author | OUATTARA, Eric | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | TUMIOTTO, Camille | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | WODRICH, Harald | |
| dc.contributor.author | BUSSON, Laurent | |
| dc.contributor.author | TRIMOULET, Pascale | |
| dc.contributor.author | THIEL, Elise | |
| dc.contributor.author | NOUZILLE, Mahissata | |
| dc.contributor.author | DUBOS, Maria | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | LAFON, Marie-Edith | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GILLERON, Veronique | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| hal.structure.identifier | Global Health in the Global South [GHiGS] | |
| dc.contributor.author | DEHAIL, Patrick | |
| dc.contributor.author | SALLES, Nathalie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| hal.structure.identifier | Global Health in the Global South [GHiGS] | |
| dc.contributor.author | MALVY, Denis | |
| dc.date.accessioned | 2022-04-22T07:30:04Z | |
| dc.date.available | 2022-04-22T07:30:04Z | |
| dc.date.issued | 2022-03-15 | |
| dc.identifier.issn | 1873-5967 (Electronic) 1386-6532 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139897 | |
| dc.description.abstractEn | OBJECTIVE: To describe COVID-19 breakthrough infections in two nursing homes (NHs) sites of active COVID-19 clusters despite optimal vaccination coverage. METHODS: A cross-sectional study was conducted in two NHs of south-western France, following the investigation of COVID-19 clusters (February-March 2021). SARS-CoV-2-confirmed infection was defined by positive RT-PCR. Antibodies neutralization capacities were tested in a subgroup of fully-vaccinated and seropositive-residents. RESULTS: Of the 152 residents, 66% were female with median age 87 years (IQR: 80.0-90.2). Overall, 132 (87%) residents received 2 doses of vaccine, 14 (9%) one dose and 6 (4%) were unvaccinated. Forty-seven (31%) residents had confirmed infection (45 (98%) with variant 20I/501Y.V1). All 6 non-vaccinated residents, 4 /14 who had one dose and 37/132 that had two doses, were infected. Of the 39 residents reporting symptoms, 12 and 3 presented severe and critical disease, respectively. One resident with a confirmed infection died. Infected-residents had a median anti-S IgG titre of 19 116.0 (IQR: 3 028.0-39 681.8 AU/mL), 19 times higher than that of non-infected vaccinated persons (1,207.0; IQR: 494.0-2,782.0). In the subgroup of 19 residents tested for neutralizing antibodies, the neutralizing titre (50%) was strongly positively correlated with the anti-S IgG titre (correlation coefficient = 0.83), and 1.5 times higher for the infected than non-infected residents [5.9 (IQR: 5.3-6.9) vs. 3.6 (2.9-3.8)]. CONCLUSION: Institutionalized elderly persons who undergo breakthrough infection develop higher titres of anti-S IgGs, which are strongly correlated with the neutralizing capacity of the antibodies. These results advocate for additional vaccine doses in this population. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | COVID-19 | |
| dc.subject.en | Vaccine | |
| dc.subject.en | Neutralizing antibodies | |
| dc.subject.en | SARS-CoV-2 | |
| dc.subject.en | Nursing homes | |
| dc.title.en | Post-vaccination SARS-cov-2 infection in nursing home residents, Bordeaux, France | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jcv.2022.105134 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35313222 | en_US |
| bordeaux.journal | Journal of Clinical Virology | en_US |
| bordeaux.volume | 149 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | ACTIVE_BPH | en_US |
| bordeaux.team | GHIGS_BPH | en_US |
| bordeaux.team | PHARES_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03648875 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-04-22T07:30:07Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
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