Biological activity of a SiO2-CaO-P2O5 sol-gel glass highlighted by PIXE-RBS methods
Idioma
en
Article de revue
Este ítem está publicado en
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2006-08-20. 2007, vol. 261, p. 488-493
Elsevier
Resumen en inglés
It is proposed in this study to observe the influence of P2O5 on the formation of the apatite-like layer in a bioactive glass via a complete PIXE characterization. A glass in the SiO2-CaO-P2O5 ternary system was elaborated ...Leer más >
It is proposed in this study to observe the influence of P2O5 on the formation of the apatite-like layer in a bioactive glass via a complete PIXE characterization. A glass in the SiO2-CaO-P2O5 ternary system was elaborated by sol-gel processing. Glass samples were soaked in biological fluids for periods up to 10 days. The surface changes were characterized using Particle Induced X-ray Emission (PIXE) associated to Rutherford Backscattering Spectroscopy (RBS), which are efficient methods for multielemental analysis. Elemental maps of major and trace elements were obtained at a micrometer scale and revealed the bone bonding ability of the material. The formation of a calcium phosphate-rich layer containing magnesium occurs after a few days of interaction. We demonstrate that the presence of phosphorus in the material has an impact on the development and the formation rate of the bone-like apatite layer. Indeed, the Ca/P atomic ratio at the glass/biological fluids interface is closer to the nominal value of pure apatite compared to P2O5 free glasses. It would permit, in vivo, an improved chemical bond between the biomaterials and bone.< Leer menos
Palabras clave en inglés
PIXE-RBS methods
biomaterials
bioactive glass
sol-gel
Orígen
Importado de HalCentros de investigación