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Biochip for astrobiological applications: Investigation of low energy protons effects on antibody performances

hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorBAQUÉ, M.
hal.structure.identifiersSE 2011
dc.contributor.authorLE POSTOLLEC, A.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorCOUSSOT, G.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorMOREAU, Thibault
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorDESVIGNES, I.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorINCERTI, S.
hal.structure.identifiersSE 2011
dc.contributor.authorDOBRIJEVIC, M.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorMORETTO, P.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorVANDENABEELE-TRAMBOUZE, O.
dc.date.created2011
dc.date.issued2011
dc.identifier.issn0032-0633
dc.description.abstractEnntibody-based micro-arrays instruments are very promising tools for the search for biomarkers in planetary exploration missions. Since such instruments have never been used in this context, it is important to test their resistance to space constraints. In particular, cosmic particles might be deleterious. In the present study, we have investigated the effect of low energy protons (2 MeV) on antibody performances with fluences levels much greater than expected for a typical mission to Mars. We show that these particles do not alter significantly the antibody recognition capability for both free (in solution) and grafted (covalently bound to the support) freeze-dried antibodies. Details of the freeze-dried drying process used to optimize antibody performances during our experiments are also presented.
dc.language.isoen
dc.publisherElsevier
dc.subject.enAntibody-based microarrays
dc.subject.enCosmic radiation
dc.subject.enLife-detection instrument
dc.subject.enPlanetary exploration
dc.title.enBiochip for astrobiological applications: Investigation of low energy protons effects on antibody performances
dc.typeArticle de revue
dc.identifier.doi10.1016/j.pss.2011.06.009
dc.subject.halPlanète et Univers [physics]/Astrophysique [astro-ph]/Planétologie et astrophysique de la terre [astro-ph.EP]
dc.subject.halPhysique [physics]/Astrophysique [astro-ph]/Planétologie et astrophysique de la terre [astro-ph.EP]
bordeaux.journalPlanetary and Space Science
bordeaux.page1490-1497
bordeaux.volume59
bordeaux.issue13
bordeaux.peerReviewedoui
hal.identifierhal-00623423
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00623423v1
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