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Proton transport in water and DNA components: A Geant4 Monte Carlo simulation

hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorCHAMPION, C.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorINCERTI, S.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorTRAN, H.N.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorKARAMITROS, M.
dc.contributor.authorSHIN, J.I.
dc.contributor.authorLEE, S.B.
dc.contributor.authorLEKADIR, H.
dc.contributor.authorBERNAL, M.
dc.contributor.authorFRANCIS, Z.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorIVANCHENKO, V.
hal.structure.identifierInstituto de Física de Rosario [Santa Fe] [IFIR]
dc.contributor.authorFOJÓN, O.A.
dc.contributor.authorHANSSEN, J.
dc.contributor.authorRIVAROLA, R.D.
dc.date.issued2013
dc.identifier.issn0168-583X
dc.description.abstractEnAccurate modeling of DNA damages resulting from ionizing radiation remains a challenge of today's radiobiology research. An original set of physics processes has been recently developed for modeling the detailed transport of protons and neutral hydrogen atoms in liquid water and in DNA nucleobases using the Geant4-DNA extension of the open source Geant4 Monte Carlo simulation toolkit. The theoretical cross sections as well as the mean energy transfers during the different ionizing processes were taken from recent works based on classical as well as quantum mechanical predictions. Furthermore, in order to compare energy deposition patterns in liquid water and DNA material, we here propose a simplified cellular nucleus model made of spherical voxels, each containing randomly oriented nanometer-size cylindrical targets filled with either liquid water or DNA material (DNA nucleobases) both with a density of 1 g/cm3. These cylindrical volumes have dimensions comparable to genetic material units of mammalian cells, namely, 25 nm (diameter) 25 nm (height) for chromatin fiber segments, 10 nm (d) 5 nm (h) for nucleosomes and 2 nm (d) 2 nm (h) for DNA segments. Frequencies of energy deposition in the cylindrical targets are presented and discussed
dc.language.isoen
dc.publisherElsevier
dc.subject.enMonte Carlo Geant4 Geant4-DNA Nucleobases Electromagnetic interactions
dc.title.enProton transport in water and DNA components: A Geant4 Monte Carlo simulation
dc.typeArticle de revue
dc.identifier.doi10.1016/j.nimb.2012.12.059
dc.subject.halPhysique [physics]/Physique Nucléaire Expérimentale [nucl-ex]
bordeaux.journalNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
bordeaux.page165-168
bordeaux.volume306
bordeaux.peerReviewedoui
hal.identifierin2p3-00835907
hal.version1
hal.popularnon
hal.audienceNon spécifiée
hal.origin.linkhttps://hal.archives-ouvertes.fr//in2p3-00835907v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nuclear%20Instruments%20and%20Methods%20in%20Physics%20Research%20Section%20B:%20Beam%20Interactions%20with%20Materials%20and%20Atoms&rft.date=2013&rft.volume=306&rft.spage=165-168&rft.epage=165-168&rft.eissn=0168-583X&rft.issn=0168-583X&rft.au=CHAMPION,%20C.&INCERTI,%20S.&TRAN,%20H.N.&KARAMITROS,%20M.&SHIN,%20J.I.&rft.genre=article


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