Novel Methods for Bioimaging Including LA-ICP-MS, NanoSIMS, TEM/X-EDS, and SXRF
| hal.structure.identifier | Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux [IPREM] | |
| dc.contributor.author | SCHAUMLÖFFEL, Dirk | |
| dc.contributor.author | HUTCHINSON, R. | |
| hal.structure.identifier | Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux [IPREM] | |
| dc.contributor.author | MALHERBE, Julien | |
| dc.contributor.author | LE COUSTUMER, Philippe | |
| hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
| dc.contributor.author | GONTIER, E. | |
| hal.structure.identifier | Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux [IPREM] | |
| dc.contributor.author | ISAURE, M.-P. | |
| dc.date.issued | 2016 | |
| dc.identifier.isbn | 9783527694907 (ISBN); 9783527339693 (ISBN) | |
| dc.description.abstractEn | This chapter presents four complementary element-specific bioimaging techniques: laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), nano secondary ion mass spectrometry (NanoSIMS), transmission electron microscopy coupled with energy-dispersive X-ray spectroscopy (TEM/X-EDS), and synchrotron-based X-ray fluorescence (SXRF). LA-ICP-MS is a spatially resolved analytical technique mainly measuring metallic elements in solidmaterials. LA-ICP-MS bioimaging analysis has been applied to cancer studies to investigate metal-ion distribution changes in diseased versus healthy tissues. SIMS is an analytical technique that relies on the sputtering of ions from a solid surface by focused positive or negative primary ion beams and the subsequent analysis of the produced secondary ions by a mass spectrometer under high vacuum. NanoSIMS and TEM/X-EDS are operated under high vacuum where the sample is exposed to a high-energy ion beam or electron beam. These facts demand specific sample preparation strategies for biological samples, which are similar for both techniques and can be regarded together. | |
| dc.language.iso | en | |
| dc.publisher | Wiley-VCH Verlag | |
| dc.source.title | Metallomics Analytical Techniques and Speciation Methods | |
| dc.subject.en | Synchrotron-based X-ray fluorescence | |
| dc.subject.en | TEM/X-EDS | |
| dc.subject.en | nano secondary ion mass spectrometry | |
| dc.subject.en | Bioimaging techniques | |
| dc.subject.en | Metallomics | |
| dc.title.en | Novel Methods for Bioimaging Including LA-ICP-MS, NanoSIMS, TEM/X-EDS, and SXRF | |
| dc.type | Chapitre d'ouvrage | |
| dc.subject.hal | Chimie | |
| dc.subject.hal | Chimie/Chimie analytique | |
| bordeaux.page | 83-116 | |
| bordeaux.title.proceeding | Metallomics Analytical Techniques and Speciation Methods | |
| hal.identifier | hal-01529884 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01529884v1 | |
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