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Accounting for radiation-induced indirect damage on DNA with the Geant 4-DNA code

dc.contributor.authorDE LA FUENTE ROSALES, Liset
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, Sebastien
dc.contributor.authorFRANCIS, Ziad
dc.contributor.authorBERNAL, Mario A.
dc.date.issued2018
dc.description.abstractEnThe use of Monte Carlo (MC) simulations remains a powerful tool to study the biological effects induced by ionizing radiation on living beings. Several MC codes are commonly used in research fields such as nanodosimetry, radiotherapy, radiation protection, and space radiation. This work presents an enhancement of an existing model [1] for radiobiological purposes, to account for the indirect DNA damage induced by ionizing particles. The Geant4-DNA simulation toolkit was used to simulate the physical, pre-chemical, and chemical stages of early DNA damage induced by protons and α-particles. Liquid water was used as the medium for simulations. Two phase-space files were generated, one containing the energy deposition events and another with the position of chemical species produced by water radiolysis from 0.1 ps up to 1 ns. These files were used as input in the radiobiological code that contains the genetic material model with atomic resolution, consisting of several copies of 30 nm chromatin fibers. The B-DNA configuration was used. This work focused on the indirect damage produced by the hydroxyl radical (OH) attack on the sugar-phosphate group. The approach followed to account for the indirect DNA damage was the same as those used by other radiobiological codes [2,3] . The critical parameter considered here was the reaction radius, which was calculated from the Smoluchowski’s diffusion equation. Single, double, and total strand break yields produced by direct, indirect, and mixed mechanisms are reported. The obtained results are consistent with experimental and calculation data sets published in the literature
dc.language.isoen
dc.title.enAccounting for radiation-induced indirect damage on DNA with the Geant 4-DNA code
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ejmp.2018.06.006
dc.subject.halPhysique [physics]
bordeaux.journalPhys.Medica
bordeaux.page108-116
bordeaux.volume51
bordeaux.peerReviewedoui
hal.identifierhal-01851229
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01851229v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Phys.Medica&rft.date=2018&rft.volume=51&rft.spage=108-116&rft.epage=108-116&rft.au=DE%20LA%20FUENTE%20ROSALES,%20Liset&INCERTI,%20Sebastien&FRANCIS,%20Ziad&BERNAL,%20Mario%20A.&rft.genre=article


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