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Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit

dc.contributor.authorMCNAMARA, Aimee L.
dc.contributor.authorRAMOS-MÉNDEZ, José
dc.contributor.authorPERL, Joseph
dc.contributor.authorHELD, Kathryn
dc.contributor.authorDOMINGUEZ, Naoki
dc.contributor.authorMORENO, Eduardo
dc.contributor.authorTHENTHORN, Nicholas
dc.contributor.authorJKIRKBY, Karen
hal.structure.identifierInstitut de Radioprotection et de Sûreté Nucléaire [IRSN]
dc.contributor.authorMEYLAN, Sylvain
hal.structure.identifierInstitut de Radioprotection et de Sûreté Nucléaire [IRSN]
dc.contributor.authorVILLAGRASA, Carmen
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, Sebastien
dc.contributor.authorFADDEGON, Bruce
dc.contributor.authorPAGANETTI, Harald
dc.contributor.authorSCHUEMANN, Jan
dc.date.issued2018
dc.description.abstractEnComputational simulations, such as Monte Carlo track structure simulations, offer a powerful tool for quantitatively investigating radiation interactions within cells. The modelling of the spatial distribution of energy deposition events as well as diffusion of chemical free radical species, within realistic biological geometries, can help provide a comprehensive understanding of the effects of radiation on cells. Track structure simulations, however, generally require advanced computing skills to implement. The TOPAS-nBio toolkit, an extension to TOPAS (TOol for PArticle Simulation), aims to provide users with a comprehensive framework for radiobiology simulations, without the need for advanced computing skills. This includes providing users with an extensive library of advanced, realistic, biological geometries ranging from the micrometer scale (e.g. cells and organelles) down to the nanometer scale (e.g. DNA molecules and proteins). Here we present the geometries available in TOPAS-nBio.
dc.language.isoen
dc.title.enGeometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit
dc.typeArticle de revue
dc.identifier.doi10.1088/1361-6560/aad8eb
dc.subject.halPhysique [physics]
bordeaux.journalPhys.Med.Biol.
bordeaux.page175018
bordeaux.volume63
bordeaux.issue17
bordeaux.peerReviewedoui
hal.identifierhal-01897238
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01897238v1
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