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Emerging chemical tools and techniques for tracking biological manganese

dc.contributor.authorDAS, Sayani
dc.contributor.authorKHATUA, Kaustav
dc.contributor.authorRAKSHIT, Ananya
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorCARMONA, Asuncion
dc.contributor.authorSARKAR, Anindita
dc.contributor.authorBAKTHAVATSALAM, Subha
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorORTEGA, Richard
dc.contributor.authorDATTA, Ankona
dc.date.issued2019
dc.description.abstractEnRecent developments in Mn biology have added new physiological and pathophysiological roles of this essential metal ion to the already existing repertoire of indispensable biological roles of Mn ions. Notably, the discovery of Mn2+ specific transporters, maladies related to mutations in these transporters, and evidence of the role of labile Mn2+ species as anti-oxidants have initiated studies targeted at elucidating Mn ion regulation and pathways implicated in pathological conditions. Closely inter-linked with the quest for understanding metal ion homeostasis are basic questions like “How are metal ions installed in their correct biological addresses where they need to function?” and “Are dynamic changes in metal ion distribution functionally relevant?” These questions become more critical in the context of Mn2+ ions, which have inherently low binding affinities toward most ligands and hence would always face competing metal ions in the biological milieu. In the emerging context of functional roles of the labile Mn2+ ion pool, the development of chemical tools and techniques that can provide information on the location, distribution and dynamic changes in these parameters under physiological and pathophysiological conditions becomes imperative. In this frontier article, we discuss the challenges that had left Mn2+ ions lagging behind in the race for the development of chemical tools and recent approaches that addressed these challenges to develop tools and techniques that can illuminate Mn ions in living systems.
dc.language.isoen
dc.title.enEmerging chemical tools and techniques for tracking biological manganese
dc.typeArticle de revue
dc.identifier.doi10.1039/C9DT00508K
dc.subject.halPhysique [physics]
bordeaux.journalDalton Trans.
bordeaux.page7047-7061
bordeaux.volume48
bordeaux.issue21
bordeaux.peerReviewedoui
hal.identifierhal-02188086
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02188086v1
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