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Complex cell geometry and sources distribution model for Monte Carlo single cell dosimetry with iodine 125 radioimmunotherapy

hal.structure.identifierLAboratoire PLasma et Conversion d'Energie [LAPLACE]
dc.contributor.authorARNAUD, François-Xavier
hal.structure.identifierInstitut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM]
dc.contributor.authorPAILLAS, S.
hal.structure.identifierInstitut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM]
dc.contributor.authorPOUGET, Jean-Pierre
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, S.
hal.structure.identifierCentre de Recherches en Cancérologie de Toulouse [CRCT]
dc.contributor.authorBARDIÈS, M.
hal.structure.identifierLAboratoire PLasma et Conversion d'Energie [LAPLACE]
hal.structure.identifierCentre de Recherches en Cancérologie de Toulouse [CRCT]
dc.contributor.authorBORDAGE, Marie-Claude
dc.date.issued2016-01
dc.identifier.issn0168-583X
dc.description.abstractEnIn cellular dosimetry, common assumptions consider concentric spheres for nucleus and cell and uniform radionuclides distribution. These approximations do not reflect reality, specially in the situation of radioimmunotherapy with Auger emitters, where very short-ranged electrons induce hyper localised energy deposition. A realistic cellular dosimetric model was generated to give account of the real geometry and activity distribution, for non-internalizing and internalizing antibodies (mAbs) labelled with Auger emitter I-125. The impact of geometry was studied by comparing the real geometry obtained from confocal microscopy for both cell and nucleus with volume equivalent concentric spheres. Non-uniform and uniform source distributions were considered for each mAbs distribution. Comparisons in terms of mean deposited energy per decay, energy deposition spectra and energy-volume histograms were calculated using Geant4. We conclude that realistic models are needed, especially when energy deposition is highly non-homogeneous due to source distribution.
dc.language.isoen
dc.publisherElsevier
dc.subject.enMonte Carlo
dc.subject.enCellular dosimetry
dc.subject.enI-125
dc.subject.enRadioimmunotherapy
dc.title.enComplex cell geometry and sources distribution model for Monte Carlo single cell dosimetry with iodine 125 radioimmunotherapy
dc.typeArticle de revue
dc.identifier.doi10.1016/j.nimb.2015.11.008
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie
dc.subject.halSciences du Vivant [q-bio]/Cancer
bordeaux.journalNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
bordeaux.page227-233
bordeaux.volume366
bordeaux.peerReviewedoui
hal.identifierhal-02294314
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02294314v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nuclear%20Instruments%20and%20Methods%20in%20Physics%20Research%20Section%20B:%20Beam%20Interactions%20with%20Materials%20and%20Atoms&rft.date=2016-01&rft.volume=366&rft.spage=227-233&rft.epage=227-233&rft.eissn=0168-583X&rft.issn=0168-583X&rft.au=ARNAUD,%20Fran%C3%A7ois-Xavier&PAILLAS,%20S.&POUGET,%20Jean-Pierre&INCERTI,%20S.&BARDI%C3%88S,%20M.&rft.genre=article


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